386 results
The primary objective of the study is:- to evaluate the burden of AF and quality of life rhythm after thoracoscopic ablation surgery and after port-access concomitant left atrial MAZE surgery by continuous rhythm monitoring (Medtronic Reveal Linq…
To determine a risk profile based on clinical correlates, circulating biomarkers, and genetic background associated with failure of the hybrid AF ablation procedure.
The FAST Therapy Trial is a prospective trial of patients with a new diagnosis of fetal SVA aimed to compare the impact of different perinatal treatment strategies from the time of SVA diagnosis to birth or death1) The primary outcome will be the…
The study will gain information on 3D movements / curvatures of the Reliance 4-Front and Reliance 4-Site ICD leads in vivo. We expect that the movements will be influenced by the type of lead (lead stiffness, which is different between the 2 lead…
To validate the use of the Livv Mobiel ECG as a reliable office/bedside screening tool in primary care practice
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presentingwith Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation utilizing the…
To demonstrate the safety and effectiveness of the IntellaNav StablePoint Catheter and Force Sensing System with DIRECTSENSE for treatment of drug refractory, recurrent, symptomatic Paroxysmal Atrial Fibrillation (PAF).
The purpose of this study is to evaluate the safety and effectiveness of the Aveir wireless dual-chamber pacemaker system in the treatment of patients with slow or irregular heartbeats.
* To assess the effect of Edoxaban versus vitamin K antagonist (VKA) on net adverse clinical events (NACE), i.e., the composite of all-cause death, myocardial infarction (MI), ischemic stroke, systemic thromboembolism (SEE), valve thrombosis, and…
The primary purpose of the LAA-CLOSURE trial is to assess the efficacy and safety of surgical closure of LAA in patients undergoing aortic valve replacement
The study objective is to compare the safety and efficacy of repeated catheter ablation within 6 months versus a hybrid procedure consisting of endoscopic epicardial surgery combined with endocardial catheter ablation (performed one-stage) in…
To develop a prediction model for ICD-therapy in a study population of ICD and CRT-D patients using a multimodal dataset containing clinical and historical data from electronic health-records, remote monitoring-data, accelerometer-derived data and…
This current study aims to assess a patient specific therapy plan for patients with persistent AF by randomizing catheter versus thoracoscopic ablation for PV isolation without adjuvant substrate ablation in those patients. Subjects will be…
The aim of this study is to quantify and characterize the outcomes of radiofrequency (RF) ablation after, and the utility of electroanatomical mapping with the Advisor* HD Grid Mapping Catheter, Sensor Enabled* (hereafter called *HD Grid*) and…
The clinical study objective is to demonstrate the acute and 12 months safety and performance of the Cryterion Cardiac Cryoablation System when used as intended.
Patients with novel onset or recurrent atrial fibrillation have an altered myocardial sympathetic activity. The quantification of sympathetic activity with 123I-mIBG scintigraphy, as well as its change over time after restoration of sinus rhythm,…
To evaluate the efficacy and safety of stereotactic arrhythmia radiotherapy in patients with therapy refractory ventricular tachycardia.
The aim of this longitudinal study is to investigate the biological variation of haemostasis variables involved in thrombosis and bleeding in patients on long-term treatment with Dabigatran. This may enable us to provide recommendations for…
The aim of the proposed study is to evaluate atrial-specific K+-channels as new drug targets for the management of AF. Blockers of atrial specific K+-channels prolong repolarisation exclusively in the atria without proarrhythmic side-effects on the…
effectiveness (presence of sinus rhythm) of a watchful-waiting approach, i.e. symptom reduction through rate-control medication and monitoring until spontaneous conversion is achieved compared to routine care, consisting of either early or delayed…