386 results
Currently, no robust clinical data are available comparing interventional ablation strategies in the setting of persistent AF with enlarged Atrium > 4 cm and longstanding persistent AF, which reflects a difficult to treat patient-subgroup.…
See section 2.2. of the protocol.The primary objective of this trial is to assess the safety of an uninterrupted dabigatran etexilate periprocedural anticoagulant regimen compared to an uninterrupted warfarin regimen in NVAF patients undergoing AF…
-To characterise total mortality risk in a prospective patient cohort of ICD candidates newly implanted for primary prophylaxis of malignant ventricular arrhythmias, compared to a non-randomised control group not implanted for primary prophylaxis.-…
To test whether an early, comprehensive, rhythm control therapy can prevent adverse cardiovascular outcomes in patients with recent-onset atrial fibrillation (AF) compared to usual care.
To determine the rate of detection of sub-clinical atrial AF (* 5 minutes) within an average of 12 months following implant of the Confirm® Implantable Cardiac Monitor in patients with known cardiovascular risk factors and left atrial enlargement,…
Primary objective:Investigate the efficacy and safety of Vernakalant in the acute conversion of AF, as compared to Amiodarone and rate control alone, in critically ill patients admitted to the medical and non-cardiac surgical ICU.Secondary objective…
To determine the add-on value of bi-atrial pacing in combination with standardised Sotalol treatment for the prevention of postoperative atrial fibrillation (POAF).
To identify genetic modifiers by means of whole-exome (or targeted-genome) sequencing of members of this founder population. Secondarily, to establish a comprehensive genotype-phenotype correlation, focussing on clinical and cellular…
Mobile phones in cryptogenic strOke patients Bringing sIngle Lead ECGs to detect Atrial Fibrillation
The main objective of this study is to compare the incidence of detected AF in cryptogenic stroke patients by the AliveCor with the incidence of detected AF by a 7-Day Holter ECG.
The aim of this study is to discover a new set of parameters to define the electropathological substrate by integrating cardiac magnetic resonance imaging (CMR) and non-invasive electrocardiographic imaging (ECGI) characteristics. In the future,…
To assess the prevalence of QTc-prolongation in patients who are prescribed two or more QTc-prolongating drugs as part of usual care, and to assess potential risk factors for that QTc-prolongation.
We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS
The aim of this study is to determine which treatment, SA or CA, is superior as a primary treatment option in patients suffering from symptomatic, drug refractory (longstanding) persistent AF.
The aim of this study is to investigate the efficacy and safety of minimally invasive surgery after five year follow up in a cohort of patients with symptomatic, drug refractory, paroxysmal or persistent AF. The patients will have an additional…
The primary objective of this study is to investigate the safety and feasibility of implanting a WATCHMAN Device in a hybrid setup for AF ablation.
Primary Objective: • Investigate if CT is a reliable modality to detect blood flow distal to the LAAO device validated by TEE.Secondary Objective(s): • Evaluate the reproducibility of position and blood flow measurements: inter and intra observer…
The purpose of this study is to determine which patients undergoing cardioversion are at risk of AF recurrence, by associating plasma biomarkers and their overtime changes to AF recurrence after 6 months follow-up.
The primary objective of this study is to evaluate if PVI performed with cryoballoon and other cryocatheters is superior to AAD as first-line therapy in preventing atrial arrhythmia recurrences
The objective of the clinical study is to evaluate the incidence of device- and procedure-related safety, efficacy, and efficiency (6-and 12-month outcomes) when using the AcQMap as an imaging and mapping system for ablation of persistent atrial…
Objectives:To collect data on effect size for, and determine the feasibility of, a full scale multicentre RCT(Randomized Controlled Trial) that1. compares the efficacy and safety of NOACs with VKA treatment according to Dutchstandards, in VKA-…