538 results
In the current study, we want to determine and correlate the results of both perfusion capacity (with MR imaging) and sublingual glycocalyx dimensions in a) patients with proven obstructive coronary artery disease and b) patients with angina but…
The primary objectives of our study are:1. to compare the diagnostic performance of coronary CTA with coronary MRA to detect significant coronary stenoses (> 50% reduction in lumen diameter), in patients with a range of coronary calcium…
The primary objective of this randomized trial is to reduce the HbA1c levels by 10% through exercise training with or without oral anti-diabetic medication in patients with coronary artery disease (PCI or CABG in stable CAD, or post STEMI and post…
The hypothesis of the FAME II trial is that FFR-guided PCI (with DES) plus optimal medical treatment is superior to optimal medical treatment alone. The overall purpose of the FAME II study is to compare the clinical outcomes, safety and cost-…
• To investigate the magnitude and time course of platelet reactivity and platelet activation in patients with a STEMI undergoing primary percutaneous coronary intervention (pPCI).• To investigate the magnitude and time course of thrombin generation…
To assess whether the iFR is non-inferior to FFR when used to guide treamtent of coronary stenoses with PCI
The purpose of the trial is to show that the early administration of bivalirudin improves 30 day outcomes when compared to the current standard of care in patients with STE-ACS, with an onset of symptoms of >20 minutes and <12 hours,…
The purpose of this clinical study is to provide confirmation of the clinical safety and performance of the CINCOR* System in removing contrast in patients at risk of developing CIN who are undergoing percutaneous coronary procedures.
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
The current research proposal therefore aims to examine the relation between a range of psychological risk factors and several mental stress-induced physiological responses in a large sample of PCI patients.
To investigate whether children with a history of Kawasaki disease have an increased IMT and arterial stifness compared to their healthy siblings.
The objective is to assess the feasibility and safety of the Axetis Inert Stent for treatment of patients with de novo coronary artery stenosis in native vessels.
To determine whether platelet reactivity unit (PRU) values as assessed with the VerifyNow P2Y12 assay are influenced by the performance of a PCI procedure
The objective for the study is to establish a proof of concept for the use of self-expandable stenting in subacute to chronic total occlusions and evaluate the safety and effectiveness of the STENTYS Coronary Stent System in the treatment of these…
In this study, we will assess the reproducibility of the observed dose-dependent inhibiting effect of CK on platelet aggregation.
To compare the diagnostic value of CTA versus the standard work-up in terms of identifying patients with severe coronary artery disease (requiring revascularization), as well as the ability to safely discharge patients without coronary artery…
1) identifying new predictors of ST, in particular of late and very late ST and drug eluting stent thrombosis2) to observe clinical outcome after an episode of a ST
The aim of this study is to perform a head-to-head comparison between SPECT/CT and PET/CT in comparison with conventional catheter-based coronary angiography and FFR measurements, to establish the diagnostic value of the modern cardiac myocardial…
To demonstrate whether using MSCT to reclassify individuals who are at high-risk based on traditional risk factors.
Primary Objective The objective of this study is to evaluate the extent of neointima formation at 3 month after (successful) implantation of the Nano+ stent in a single lesion in elective PCI patients. Secondary Objective To assess if NanoTM Polymer…