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Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an
All COmeRs PopulaTion (BIO-RESORT): Randomized Multicenter Trial in an All Comers Population Treated Within thE NeThErlands 3 (TWENTE 3)

The aim of the study is to compare the outcome of two DES with biodegradable polymer coatings separately (Orsiro and Synergy) versus an established third-generation durable polymer DES with proven efficacy and safety (Resolute Integrity) in an all…

Amsterdam Investigator-initiateD ABSORB trial- AIDA CTO Physiology

To compare the endothelium-dependent and non-endothelium-dependent vasomotion and perfusion restoration in coronary vessels treated with ABSORB BVS or Xience DES in CTO coronary lesions

Amsterdam Investigator-initiateD Absorb strategy all-comers trial

Primary Objective: To compare the strategies of treatment with 1. ABSORB everolimus eluting bioresorbable vascular scaffolds and 2. Xience everolimus eluting coronary stent system in a non-inferiority all-comers trial.

Bifurcation ABSORB OCT Trial

Primary Objective:To compare the fate of the struts in front of the side-branch and intimal bridge formation using optical coherence tomography after treatment with the bioresorbable everolimus eluting vascular scaffold of coronary bifurcation…

A Prospective Multicenter Trial to Assess the Safety and Effectiveness of the
SYNERGYTM Everolimus-Eluting Platinum Chromium Coronary Stent System
(SYNERGYTM Stent System) for the Treatment of Atherosclerotic Lesion(s)

To assess the safety and effectiveness of the SYNERGYTM Coronary Stent System for the treatment of subjects with atherosclerotic lesion(s) * 34 mm in length (by visual estimate) in native coronary arteries *2.25 mm to *4.0 mm in diameter (by visual…

A clinical evaluation to compare the safety, efficacy and performance of
ABSORB everolimus eluting bioresorbable vascular scaffold against
XIENCE PRIME everolimus eluting coronary stent system in the
treatment of subjects with ischemic heart disease caused by de novo native
coronary artery lesions

To compare the safety, effectiveness and performance of TM ABSORB bioabsorbable everolimus eluting vascular scaffold against XIENCE PRIME TM everolimus eluting coronary stent system in treating people with ischemic heart disease caused by de novo…

DUrable Polymer-based STent CHallenge of Promus ElemEnt versus ReSolute Integrity (DUTCH PEERS): Randomized Multicenter Trial in All-Comers Population Treated Within
Eastern NeThErlands-2 (TWENTE-2)

Primary research questions To investigate whether the outcome after the randomized implantation of the Resolute Integrity® versus Promus Element® drug-eluting stent are similar, as assessed in a non-inferiority setting by comparing target-vessel…

The effects of on the rheologic properties and oxygen transport capacity of red blood cells processed by 3 different types of cell savers, and its effects on microcirculatory blood flow and tissue oxygenation in vivo

The objective of this study is to determine in vitro the rheologic and oxygen transport capacity of the washed blood processed by one of 3 different cell savers and to measure in vivo after retransfusion of this processed blood in the patient the…

Revascularization with paclitaxel-coated balloon angioplasty versus drug-eluting stenting in acute myocardial infarction - a randomized controlled trial

This randomized controlled trial is designed to prospectively assess the safety and efficacy of a CE-marked paclitaxel-eluting balloon only strategy versus third generation DES in the setting of a STEMI. This inferiority design serves to demonstrate…

Comparison of Titanium-Nitride-Oxide coated Bio-Active-Stent (Optimax*) to the Drug (Everolimus) -Eluting Stent (Synergy*) in Acute Coronary Syndrome

The purpose of the trial is to compare the safety and effectiveness of bio-active-stent (BAS; Optimax*) and everolimus-eluting stent (EES; Synergy*) in patients presenting with acute coronary syndrome

Processing intra-operative blood loss by two different techniques does it affect the donor blood consumption?
A prospective randomized pilot study.

This pilot study compares two existing techniques to see if there's a differt in donor blood consumption.

A multicenter, prospective randomized study to compare vascular healing after deployment of the Abluminal Sirolimus Coated Bio-Engineered Stent (Combo Bio-Engineered Sirolimus Eluting Stent) versus the Everolimus Eluting Stent in patients with Acute Coronary Syndrome by means of Optical Coherence Tomography

See also page 19 (section 6) of the protocol:6. Study ObjectiveIt is the objective of this study to assess vascular healing by Optical Coherence Tomography (OCT) analysis after deployment of the Abluminal Sirolimus Coated Bio-Engineered Stent (Combo…

CLINICAL INVESTIGATION OF A DES (MISTENT* SYSTEM) WITH SIROLIMUS AND A BIOABSORBABLE POLYMER FOR THE TREATMENT OF PATIENTS WITH DE NOVO LESIONS IN NATIVE CORONARY ARTERIES

The primary objective of this study is to demonstrate whether the MiStent Drug Eluting Coronary Stent System can safely and effectively improve coronary luminal diameter in patients with symptomatic ischemic heart disease due to discrete de novo…

Preservation of microcirculatory perfusion after pulsatile cardiopulmonary bypass: the role of prothrombogenic processes and the endothelium.

We aim to investigate whether pulsatile flow in patients subjected to CPB preserves postoperative microcirculatory perfusion by prevention of a prothrombogenic profile and endothelial activation as are both present under non-pulsatile flow…

RAndomized comParison between the Stentys self-exPanding COronary Stent and a balloon-expandable stent In AcuTe MyocardIal InfarctiON

The primary objective is to assess the safety and operation of the Stentys coronary stent system in patients with acute myocardial infarction compared with a balloon-expanding stent. These are the effect and safety in the short term (the procedure…

A 2x2 Factorial, Randomized, Multicenter, Single-Blind Evaluation of Intracoronary Abciximab Infusion and Aspiration Thrombectomy in Patients Undergoing Percutaneous Coronary Intervention for Anterior ST-Segment Elevation Myocardial Infarction

The primary objective of the study is to demonstrate that among subjects undergoing primary PCI for anterior STEMI treated with a bivalirudin monotherapy anticoagulation strategy, the intracoronary infusion of an abciximab bolus with or without…

Comparison of the everolimus eluting (XIENCE-V*/XIENCE-PRIME* or PROMUS* stent) with the biolimus A9 eluting NOBORI* stent in all-comers: a randomized open label study.

The main objective of the study is to investigate whether of the biolimus eluting and biodegradable polymer NOBORI* stent is non-inferior or even superior to the everolimus eluting XIENCE-V/XIENCE-PRime/PROMUS* stent in daily practice.

A Prospective, Randomized, Multi-center Trial to Assess the Everolimus-Eluting Coronary Stent System (PROMUS Element) for Coronary Revascularization in a Population of Unrestricted Patients

To determine the safety and effectiveness of Boston Scientific*s Everolimus-eluting coronary stent system (PROMUS Element*) for coronary revascularization in an unrestricted population compared to the Xience* Prime control.

A Prospective, Randomized Study to Evaluate the Safety and Effectiveness of
an AbluMinal Sirolimus CoatED Bio-Engineered StEnt (Combo Bio-
Engineered Sirolimus Eluting Stent) Compared with a TAXUS® Liberté® Stent
Control Arm for Treatment of Stenotic Lesions in Native Coronary Arteries

The primary objective of this clinical trial is to demonstrate the safety and effectiveness of the Combo Bio-engineered Sirolimus Eluting Stent (Combo Stent) compared to the commercially available TAXUS® Liberté® Paclitaxel-Eluting Stent (DES) in…

Drug Eluting Balloon in Acute Myocardial Infarction

The purpose of the study is to compare the combination of DEB/BMS versus DES versus BMS alone in patients with an AMI.