Search for a trial

Effect of iodine concentration on Vascular Attenuation
in CT Coronary Angiography

· Explore the relative impacts of iodine concentration versus iodine delivery rate on intra-coronary attenuation. · Describe the effect of iodine concentration on contrast bolus characteristics e.g. bolus homogeneity, time-to-peak, and pressure…

Randomized study to assess the effect of thrombus aspiration on flow area in STEMI patients: an Optical Frequency Domain Imaging (OFDI) study

To evaluate whether primary percutaneous coronary intervention (primary PCI) with a new thrombectomy device as compared to primary PCI without thrombectomy increases minimal flow area after stenting for treatment of patients presenting with ST-…

Bifurcation Lesion Analysis and Stenting

Primary Objective: To demonstrate that IVUS with VH guidance leads to better post procedural outcome when compared to angiographic guidance only.Secondary Objective:To demonstrate that IVUS and VH guidance leads to lower occurrence of MACE at short…

The effect of haemoadsorption in relation to the cytokine concentration during cardiothoracic surgery procedures while using extracorporeal circulation.

The aim of the study is, to analyze the effect of the haemoadsorption device Cytosorb in relation to the inflammatory parameters IL-6, IL-8, IL-10,TNF-* and CRP at six different time points during conventional CABG procedures.We assess whether the…

OPtimal stEnt deployment stRategy oF Contemporary sTents

Primary objectiveThe primary objective is to evaluate whether a standard pre- and postdilatation of the modern DES results in a more optimal stent implantation compared to DS as evaluated by OCT in patients with stable coronary artery disease.…

Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting;Substudy: Characterization of Intermediate Lesions

• Demonstrate that PCI guided by iFR Co-registration is associated with superior clinical outcomes compared to PCI guided by angiography alone• To evaluate the cost-effectiveness of physiology guidance with SyncVision compared to a standard of care…

COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events

Primary Objective: To prove that in patients with multivessel coronary disease (MVD) (>= 2 lesions with diameter stenosis >=50%) a PCI revascularization strategy based on revascularisation of all lesions presenting a vulnerable plaques…

OPtical Coherence Tomography (OCT) Guided Coronary Stent IMplantation Compared to Angiography: a Multicenter Randomized TriaL in PCI

The objective of this clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent implantation strategy in achieving larger post-PCI…

Non-inferiority of Angiography-derived Physiology Guidance Versus Usual Care in an All-comers PCI Population Treated With Unrestricted Use of the Healing-Targeted Supreme (HT Supreme) Drug-eluting Stent and P2Y12 Inhibitor Monotherapy After 1-month of Dual-antiplatelet Therapy: the PIONEER IV trial

This PIONEER IV trial aims to demonstrate a non-inferiority of QFR-guidance PCI to usual care PCIwith respect to Patient oriented Composite Endpoint (PoCE) at 1 year with the unrestricted use ofHT Supreme-SES in an all-comers population (including…

MitoPO2 guided resuscitation to prevent shock during cardiac surgery

To compare the use of mitoPO2 with the use of conventional markers in guiding interventions to treat shock in patients undergoing cardiac surgery