84 results
Primary objective: To investigate left ventricular diastolic function in AS-patients compared with osteoarthritis patients. Secondary objectives: To assess the prevalence of valvular heart diseases and conduction disturbances. To assess left…
The objective of the present study is to investigate whether home-based exercise training with telemonitoring guidance results in improved long-term physical fitness and higher activity levels than regular centre-based exercise training in patients…
Study 1:1) To test the hypothesis that Liraglutide improves cardiovascular function in DM2 patients and whether the improvement is associated with redistribution of ectopic fat stores. 2) To test the hypothesis that Liraglutide activates BAT in DM2…
Within this project we aim to determine the energetic conditions that underlie the transition to hypertrophy of the HOCM heart. A prospective comparison will be made between results of PET, MRI and function of cardiac myofilaments (in vitro). Also,…
The aim of this observational study is to obtain the evidence base to improve CR programmes regarding sustainable effectiveness, cost-effectiveness and participation level in elderly patients, by comparing 8 currently available CR programmes. The…
Primary:To obtain paediatric pharmacokinetic data of enalapril and its active metabolite enalaprilat in paediatric patients treated with enalapril ODMTs to describe the dose exposure in the paediatric population with DCM.Secondary:1. To demonstrate…
We hypothesize that the amount of physical activity correlates with insulin-induced microvascular recruitment during free-fatty acid infusion in skeletal muscle as well as in the heart. In this study we aim to test this hypothesis.
To assess the effects of marathon running on changes in cardiac and skeletal muscle structure and function using state of the art MRI techniques, ultra-sensitive biomarker assays and a high resolution 64-lead electrocardiogram.
The purpose of the sub-study is to do research into markers which will hopefully assist to diagnose the condition Peripartum Cardiomyopathy as early as possible. The blood donated for research will also assist in the assessment of women having a…
The main objective of this study is to evaluate whether myocardial ischemia in the absence of obstructive CAD in athletes is associated with a reduced myocardial perfusion when compared to control subject with a low a priori risk of CAD and without…
Since October 2010 the Catharina-hospital in Eindhoven offers a cardiac rehabilitation program to cardiovascular patients. As an optional section of the program an adjusted training of MBSR is offered, called *stress reduction in cardiovascular…
Primary ObjectiveThe primary objective of this study is to compare prospectively in patients treated with TCZ or etanercept (ETA), the time to first occurrence of any component of a composite of major adverse cardiovascular events (MACE) consisting…
The purpose of the study is to investigate to what extent GNX-5086 is tolerated. It will also be investigated how quickly and to what extent GNX-5086 is absorbed and eliminated from the body (this is called pharmacokinetics).
The primary objective of this study is to assess the neointimal healing score (as evaluated by intra-coronary OFDI) in patients with STEMI and treated with Abbott Vascular ABSORB everolimus eluting bioresorbable vascular scaffold (BVS) at 6 months…
To examine the effect of remote ischemic preconditioning on exercise-induced cTn elevations and indices of cardiac function.
To assess the impact of eplerenone on cardiovascularmortality and morbidity in patients with acutemyocardial infarction (STEMI) when initiated withinthe first 24 hours of onset of symptoms (preferablyduring the first 12 hours)To investigate the…
The objective of this study is to determine the Safety and Efficacy of ADRCs delivered via the intracoronary route in the treatment of patients with ST-elevation acute myocardial infarction (STEMI).Investigation of stem and regenerative cell therapy…
To compare cerebral activity patterns during emotional and cognitive processing among patients with post-MI depression and patients with regular depression.
The aim of this study is to investigate the temporal dynamics between depressive symptoms and physical activity in post-MI patients, in order to prevent the deleterious effects of depression on heart disease prognosis and improve patient counselling…
The aim of this study is to identify risk factors for various CVDs, i.e. to quantify separate and joint effects of radiation dose to the heart, anthracycline dose, other CT, life style factors, established CVD risk factors and genetic susceptibility…