47 results
The primary objective of this study is to investigate whether circulating fibrotic biomarkers are related to the amount of cardiac fibrosis as determined by MRI in patients. Secondarily, this study aims to investigate whether these biomarkers are…
Primairy objectives:1.To investigate whether a non-invasive imaging guided strategy (either CTA or CMR) early in the diagnostic process reduces the number of patients with at least one ICA during the initial admission as compared to routine clinical…
Primary Objective: To assess the analytical performance of the cardiac reader Secondary Objective(s): To assess the user friendliness of the device (handling, analytical speed).
The objectives of this study in STEMI patients are as follows:Primary objectives: - To investigate the kinetics of AGEs in the acute phase of STEMI by repeated measurements with the AGE reader® through skin AF, as well as by determining serum AGEs…
To assess the circadian variation of cardiac troponins in individuals without any evidence of active cardiovascular disease.
The main objective of this study is to explore two novel MRI techniques to characterize myocardial properties that are expected to be useful for the diagnosis of various forms of cardiomyopathy. Furthermore, we will explore whether different stages…
The feasibility of direct-detection of fibrotic tissue will be assessed in patients with a healed myocardial infarction and in patients with cardiomyopathy using LGE as reference standard.
The project determines the value of a novel method of measuring cardiac cTnI at the patient*s bedside (point of care testing). The study aims to assess the analytical and clinical performance of a point of care troponin I test using an novel…
1) To demonstrate an elevated troponin concentration before exercise and a rise of troponin after exercise in both pre-clinical HCM mutation carriers and HCM patients with the hypertrophic phenotype, 2) To evaluate the troponin rise in relation to…
1. Creating a reproducible and valid method for adenosine measurement2. Studying the effect of dipyridamole on the endogenous adenosine concentration before and after CPT.
To determine whether perioperative myocardial ischemia is associated with adverse outcome in patients scheduled for major abdominal surgery.
This investigation aims to test a new, better and faster method voor measurement of the LVEF, that does not depend on technetium. The method relies on the tracer Gallium-citrate, a well-known molecule that is available in unlimited quantities in-…
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
Creating a reproducible and valid method for adenosine measurement
To assess the diagnostic value of adenosine myocardial stress perfusion MR in the functional evaluation of patients undergoing a standard PCI with FFR-measurements for single or two vessel disease.
In this study we investigate the prehospital use of a Tele-ECG and the CardioDetect. We will use the results to see if help of these diagnostic tools will raise the percentage necessary hospitalisations.We will also investigate the diagnostic…
In this pilot study we investigate the use of these extra diagnostic tools. We also will use the results to see if these tools can diagnose cardiac events in patients that would otherwise be sent home
To establish the value of a new, sensitive tropnion I assay in the rapid diagnosis of minimal myocardial damage.To establish whether BNP concentration in the blood of patients with acute, minor myocardial damage has prognostic significance.
The aim of this project is to study SNPs in genes involved in the cholesterol lowering pathway and in the anti-inflammatory pathway of statins to explain differences in the protective effect of statins against myocardial infarction (MI). A second…
The aim of this *proof-of-principle* study is to demonstrate that 18F-florbetaben PET can detect amyloid deposition in the myocardium in patients with proven cardiac amyloidosis and excluded amyloid deposition in the myocardium of healthy subjects.…