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The effects of nanoparticles and ambient particles on brain function using quantitative electro-encephalography (QEEG) in healthy volunteers

To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…

Multi-locus approach in pharmacogenetics. Application in the cholesterol lowering and anti-inflammatory pathways of statins

The aim of this project is to study SNPs in genes involved in the cholesterol lowering pathway and in the anti-inflammatory pathway of statins to explain differences in the protective effect of statins against myocardial infarction (MI). A second…

Evaluation of the association between heart type fatty-acid binding proteins and high sensitive troponin and postoperative myocardial infarction in patients undergoing cardiac-surgery

The objective is to estimate the association between biomarkers of myocardial injury and myocardial infarction in patients undergoing cardiac surgery. Myocardial infarction will be established with both a new and very early marker of myocardial…

The CRYSTAL study: CMR of intraventricular flow analysis and genetic phenotyping in Hypertrophic Cardiomyopathy (HCM): a roadmap for surgical myectomy

The primary objective of this study is to assess wall shear stress in the left ventricle outflow tract using 4D flow CMR in healthy controls, asymptomatic HCM and before and after surgical myectomy in patients with HOCM,

A PROSPECTIVE MULTINATIONAL STUDY OF THE NATURAL HISTORY OF PARTICIPANTS WITH BAG3 MUTATION ASSOCIATED DILATED CARDIOMYOPATHY

Primary:Determine baseline and changes over time in cardiac structure and function in BAG3 associated DCM.Secondary:Assess the progression of prognostic disease biochemical biomarkers in BAG3 associated DCM.

Seroprevalence Study of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV) in Patients with Plakophilin 2 (PKP2)-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

PrimaryInvestigate the seroprevalence of pre-existing antibodies to AAV in patients with PKP2-associated ARVCSecondaryTo characterize the burden of illness in patients with pathogenic or likely pathogenic PKP2 mutationsTo characterize arrhythmic…