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The CRYSTAL study: CMR of intraventricular flow analysis and genetic phenotyping in Hypertrophic Cardiomyopathy (HCM): a roadmap for surgical myectomy

The primary objective of this study is to assess wall shear stress in the left ventricle outflow tract using 4D flow CMR in healthy controls, asymptomatic HCM and before and after surgical myectomy in patients with HOCM,

Evaluation of GeranylGeranylAcetone in heart failure with preserved ejection fraction

Primary objectivesTo study whether Geranyl-Geranyl Acetone (GGA) reduces left ventricular (LV) diastolic dysfunction in patients with HFpEF compared to placebo (and to assess/confirm its effectiveness and safety in patients with HFpEF)Secondary…

Assessment of myocardial function, endothelial function and perFUSION in early and advanced disease stages of Hypertrophic CardioMyopathy: FUSION-HCM

In different stages of HCM, to measure the: - Myocardial perfusion- Myocardial function- Volume parameters of the heart- Fibrosis- Function of the small vessels (endothelial (dys)function)- Diastolic function and strain of the heart

The diagnostic value of late enhancement photon counting CT in myocardial scar with usage of different contrast media
ILLUMINATE

To determine the feasibility of late enhancement imaging in spectral photon counting CT to detect myocardial infarction and viability

Focus on Energy Metabolism in Arrhythmogenic Cardiomyopathy

To determine whether a standardized exercise workload elicits a different response on 1) metabolites/cardiac biomarkers in the general circulation (measured by blood values), and 2) contraction patterns in local myocardium (measured by…

A PROSPECTIVE MULTINATIONAL STUDY OF THE NATURAL HISTORY OF PARTICIPANTS WITH BAG3 MUTATION ASSOCIATED DILATED CARDIOMYOPATHY

Primary:Determine baseline and changes over time in cardiac structure and function in BAG3 associated DCM.Secondary:Assess the progression of prognostic disease biochemical biomarkers in BAG3 associated DCM.