146 results
To investigate the tolerability and effect of pure cafeine food suplement pre-administration on myocardial [18F]FDG uptake suppression.
The primary objective is to investigate whether treatment with JAK inhibitors improves cardiac function, reduces myocardial inflammation and favourably alters coronary plaque morphology in patients with rheumatoid arthritis. The secondary objective…
Main objective: to measure the effect of trimetazidine on myocardial external efficiency in asymptomatic MYH7, MYBPC3 or TNNT2 mutation carriers Secondary objectives: to study the effect of trimetazidine on diastolic function, left ventricle and…
Primary ObjectiveTo evaluate the safety and tolerability of dutogliptin in combination with filgrastim in subjects with STEMI compared with placebo Secondary ObjectivesTo assess preliminary efficacy of dutogliptin in combination with filgrastim in…
The main objective:- To assess the PD properties of a single subcutaneous injection of RUC-4 in STEMI patients presenting to the CCL with the aim to perform primarycoronary angioplasty.- To assess the PK properties of a single subcutaneous injection…
The objective of this study is to identify biomarkers predictive for the development of HCM in asymptomatic MYBPC3 mutation carriers and to identify prognostic biomarkers in mutation carriers in whom the disease has already been revealed. In order…
Primary objectives1. To evaluate the pharmacokinetic (PK) profile of the parent compound (anethole trithione, ATT) and its main metabolite (5-[4-hydroxyphenyl]-3H-1,2-dithiole-3-thione, ATX ) following administration of a range of doses of i.v.…
To evaluate the efficacy and safety of STS compared to placebo treatment on myocardial infarct size in patients presenting with STEMI and treated with PCI and in adjunction to optimal reperfusion therapy.
The primary objectives of this project are the identification of biomarkers in the blood and skeletal muscle that can improve the diagnosis of viral myocarditis and the expansion and improvement of the viral diagnostics in these patients. However,…
Although this procedure has been performed for more than 20 years and clinical results after myectomy combined with AMVLE are satisfactory, very little is known about the effect of surgical myectomy intervention on the blood flow through the aortic…
In different stages of HCM:- To measure myocardial fatty acid oxidation, uptake and esterification- To measure myocardial glucose uptake en oxidation- To measure myocardial perfusion- To measure myocardial function- To measure volume parameters of…
Identify, if any, both structural and functional changes related to LVOT desobstruction in asymptomatic with exertional LVOT pressure gradients >50 mmHg (or >30 mmHg in rest)
To evaluate the effect of MEDI6012 on infarct size compared with placebo.
This study aims to assess early cardiac damage by means of GLS in newly diagnosed BC patients treated with anthracycline-based chemotherapy, and to investigate whether myocardial damage as measured with T1 / T2 CMR mapping and plasma hs-Troponin T…
The primary objective is to compare the analytical performance (method and sample comparison) of Minicare high sensitive troponin I testing (POC, different sample types) and conventional venipuncture troponin I test in our central hospital…
The primary aim of the study is to determine how microcirculation is affected at the bedside during fluid resuscitation and de-escalation phase of fluid therapy during surgery and in post-ICU cardiac surgery patients. The secondary aims of the study…
This study has been transitioned to CTIS with ID 2024-514372-40-00 check the CTIS register for the current data. Primary objective: To assess the effect of FDY-5301 on cardiovascular mortality and heart failure events in subjects with an anterior…
primaryTo evaluate the effect of MEDI6570 on non-calcified coronary atherosclerotic plaques compared with placebosecundaryTo evaluate the effect of MEDI6570 on a surrogate biomarker of HF compared with placeboTo evaluate the effect of MEDI6570 on…
The primary objective of this study is to assess wall shear stress in the left ventricle outflow tract using 4D flow CMR in healthy controls, asymptomatic HCM and before and after surgical myectomy in patients with HOCM,
This study has been transitioned to CTIS with ID 2023-505438-85-00 check the CTIS register for the current data. The primary objective of the study is to assess the clinical efficacy of selatogrel when self-administered upon occurrence of…