22 results
ln this study the effect of 1 novel compound on the development of psoriasis in the humanized mouse model isinvestigated.
This is a pilot study with the objective of studying the effect of vaselin on TSLP expression in nonlesional human AD skin.
In the present study we sought to determine the levels of IL-1 cytokines in the SC and to relate them to FLG genotype, pH and the levels of filaggrin degradation products. Furthermore, we aim to investigate whether FLG genotype status relates to the…
The objective of the study is mapping and assessing of the effects of filaggrin mutation on atopic eczema and other atopic diseases together with serological parameters.
The main study objective is to determine the time to, as well as number of exacerbations of atopic dermatitis in the study period between the study groups A and B.The secondary objectives are the differences in transepidermal water loss and Quality…
The effect of the intervention on pain an regain of function in de affected extremity. This will be quantified in multiple questionnaires at baseline and three follow-up points, and by clinical evaulation of the hand function at baseline and two…
Primary objectiveTo compare the efficacy of subpurpuric pulsed dye laser treatment with different intervals between treatment sessions.Secondary objectiveTo evaluate the safety and the long-term effects of subpurpuric pulsed dye laser treatment.
The present proposal aims at detecting the pathogenesis of keloids in RTS by studying 50 RTS individuals from 3 countries (Netherlands, Norway, UK) with keloids clinically, and take 3 biopsies in 5 of them from normal skin, edge of normal skin-…
This research aims to conduct blistering and reduce freguent dressing changes in patients undergoing total hip replacement or total knee replacement have undergone in the use of Aquacel Surgical dressing.This compares with the usual method of wound…
Finding an effective and permanent treatment against keloid.
In this project we would like to find out whether Sellotape stripped healthy skin can be used as an in vivo model for mechanical skin damage. This would contribute to more knowledge about growth, differentiation, inflammation and mechanical…
The objectives of this study are to determine the safety and efficacy of two doses of adalimumab versus MTX in paediatric subjects with chronic plaque psoriasis, to determine the time to loss of disease control and the ability to regain response…
Primary objective: to evaluate the efficacy of subcutaneous application of methotrexate in patients with moderate to severe Psoriasis compared to Placebo as assessed by achieving the primary endpoint PASI 75 after a 16 week treatment phase.…
Primary Objective:The primary objectives of the study are to demonstrate:• Superiority of LAS41008 versus placebo based on the proportion of subjects achievingPASI 75 at week 16 (a 75% reduction in the Psoriasis Area and Severity Index, PASI,…
To determine whether we should add ascaridole to the patch test and to differentiate between a truely positive allergic reaction and an irritant reaction. What is the relevant patch test concentration of ascaridole?
To determinate the efficacy and safety of golimumab in patients with psoriatic arthritis in daily clinical practice prospectively. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study and…
The main study objective is to determine the time to, as well as number of exacerbations of atopic dermatitis in the study period between the study groups A and B. The secondary objectives are the differences in transepidermal water loss and Quality…
Our primary objective is to visualize the vascular involvement in the pathogenesis of psoriasis with the TOPCam. In particular we asked the following questions:(i) Can the TOPCam image the structure of vascular changes in the clinical lesions?(ii)…
ln this study the effect of 1 novel compound on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to a registered drug, Ustekinumab.
The aim of the current proposal is to investigate the effects of changes in lifestyle, food intake, physical activity and health related behavior during adolescence on development of asthma, allergy and other chronic diseases. Health outcomes that…