30 results
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
Primary Objective: Investigate whether early valganciclovir treatment of children with SNHL of * 20 dB, unilateral or bilateral, and a confirmed congenital CMV infection can prevent deterioration of the hearing loss at follow-up (age 18 * 22 months…
1) Does FSAP activation in plasma of HAE patients contributes to bradykinin formation? 2) Study the inhibitory efficacy of c1-inhibitor towards kallikrein and FSAP towards bradykinin formation in a endothelial cell-based system. 3) test the efficacy…
This study's major aim is to determine whether a relation can be found between specific penile HPV types and the presence, quantity and size of flat penile lesions. Secondly, other possible determinants, such as HIV status, circumcision status…
To assess the percentage of patients with at least one subtherapeutic infliximab trough serum concentration, being < 1 mg/l.To assess the percentage of patients positive for AIAs at a minimum of one timepoint.To assess the percentage of…
The major aim is to apply deep sequencing technology to obtain a detailed unbiased overview of the bacterial microbiome of human skin. This will be performed in healthy individuals, psoriasis patients and atopic dermatitis patients. Furthermore, we…
Objective: The main objective is to compare staples versus sutures for wound closure after Total Hip Arthroplasty.
Primary Objective: Investigate whether early valganciclovir treatment of children with SNHL of >= 20 dB, unilateral or bilateral, and a confirmed congenital CMV infection can prevent deterioration of the hearing loss at 1 year follow-up.…
Primary research question:Will the use of Aquacel Ag Surgical as a postoperative wound dressing result in less postoperative wound infections?
The aim is to understand which individuals benefit from antibiotics.
Primary Objective: To show superiority of the novel fixtures compared to standard fixtures regarding stability of the implants measured as ISQ values.Secondary Objectives: 1. To compare the long time survival of the standard fixtures and abutments…
Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…
Aim of the studyIn addition to the aims of the compassionate use protocol.To study:1. hypothalamic structure before and during leptin therapy2. hypothalamic function before and during leptin therapy
The primary objective of the study is to reject the Null hypothesis: A 7 to 21 day therapy with moxifloxacin, 400 mg once daily is more than 10 % less effective than a 7 to 21 day therapy with piperacillin/tazobactam three times daily possibly…
Clinical trial to investigate a difference in effectiveness for the treatment of intertrigo in wich the combination of zinc oxide 10% in ketoconazole will to be compared with zinc oxide 10% and hydrocortisone-acetaat 1% in ketoconazole.
In this study we want to study:1) what is the prevalence of CA-MRSA asymptomatic carriership among MSM policlinic visitors?2) What are risk factors for CA-MRSA carriership and/or infections among MSM?3) Is CA-MRSA among MSM transmitted through…
The objective of this open label phase IIa trial is to evaluate the efficacy and tolerability of a once a week dose of 200 mg R126638, for a maximum of 12 weeks, for the treatment of toenail onychomycosis.
1. To study the possible association between MBL-deficiency and the occurence and severity of infections in MBL-deficient CF patients.2. To study the possible association between MBL-deficiency and the severity of cystic fibrosis.3. To study the…
The aim of this study is to determine to what extent MBL-2 polymorphisms influence the outcome of polytraumapatients. Serious (systemic) infections and local infections are the main outcome parameters. The MBL-status will be measured by determining…
The objective of this study is to evaluate the efficacy and safety of risankizumab compared with secukinumab for the treatment of adult subjects with moderate to severe plaque psoriasis who are candidates for systemic therapy.