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Markers for neurocognitive impairment in congenitally CMV infected infants: MARVELYS study

1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…

Analysis of the skin microbiome in health and disease

The major aim is to apply deep sequencing technology to obtain a detailed unbiased overview of the bacterial microbiome of human skin. This will be performed in healthy individuals, psoriasis patients and atopic dermatitis patients. Furthermore, we…

Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe: GRACE Workpackage 9: Study on the aetiology, diagnosis and prognosis of lower respiratory tract infections in primary care

Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…

Effects of leptin therapy on hypothalamic structure and function in congenital lipodystrophy

Aim of the studyIn addition to the aims of the compassionate use protocol.To study:1. hypothalamic structure before and during leptin therapy2. hypothalamic function before and during leptin therapy

HPV infections of the penis among men who have sex with men

This study's major aim is to determine whether a relation can be found between specific penile HPV types and the presence, quantity and size of flat penile lesions. Secondly, other possible determinants, such as HIV status, circumcision status…

Influence of Mannose-Binding Lectin Polymorphisms on Infectious Complications in Trauma Patients

The aim of this study is to determine to what extent MBL-2 polymorphisms influence the outcome of polytraumapatients. Serious (systemic) infections and local infections are the main outcome parameters. The MBL-status will be measured by determining…

The influence of mannose-binding lectin (MBL) on the course of disease in patients with cystic fibrosis (CF).

1. To study the possible association between MBL-deficiency and the occurence and severity of infections in MBL-deficient CF patients.2. To study the possible association between MBL-deficiency and the severity of cystic fibrosis.3. To study the…

Clinical, virological, immunological, psychosocial and epidemiological consequences of the human MonkeypoX Virus outbreak, a PROspective observational cohort study (pro-MPX)

The aim of this study is to improve our understanding of clinical, virological, and psychosocial outcomes in patients with MPXVID. To get a better understanding of associated risk factors for MPXV infection, and to measure quality of life and stigma…

Non-Tuberculous Mycobacterial Skin and Soft Tissue Infections: Using a Site-of-Disease Approach to Understand Pathophysiology and Improve Outcome

To identify clinical and immunological parameters that predict the course of disease of non-tuberculous mycobacterial skin and soft tissue infections.