87 results
The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…
More sustained knowledge of the intracellular processes regarding S1P in lymphocytes could be beneficial in modulating specific immune responses in transplantation medicine, autoimmune diseases and sepsis. Therefore, in this study, we will…
The purpose of this study is to investigate how quickly and to what extent PF-06650833 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). PF-06650833 is not registered as a drug, but…
Determine if there are immunological or patient characteristics in UC patients that predict the endoscopic response on Vedolizumab treatment.
With this pilot feasibility study, the feasibility of and satisfaction with an eHealth and serious gaming training based on psychological expectancy mechanisms are evaluated.
In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.
The objective of the current study is to obtain normative data of healthy individuals on brain measures, cognition and blood markers. In addition, we acquire information on childhood trauma, metabolic and immunological parameters in a cohort of…
ln this study effect of 3 novel compounds on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to one registered drug, namely Remicade(R).
1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.
The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…
Characterization and extending the use of the humanized mouse model for psoriasis for pre-clinical testing of new drug.Limited screening of compound B for a pharmaceutical company.Therefore, depending on the success rate of transplantation and…
The aim of this study is to assess the effect of training on the measurement properties of a recently developed disease activity score based on patient reported outcomes and to investigate if such a measure could be implemented in current clinical…
Primary objective:To investigate the effects of the three investigational products (1.Citrus e fructibus / Cydonia e fructibus as a whole, single preparations 2. Citrus e fructibus and 3. Cydonia e fructibus) on the changes in SAR related…
In previous projects a number of compounds were tested that had a positive effect in the transplant model of psoriasis. However, it proved difficult to prepare formulations that were stable enough to use in clinical studies. A new compound (CD07813…
ln this study the effect of 2 novel compounds on the development of psoriasis in the humanized mouse model is investigated. The efficacy is compared to one registered drug, namely Stelera.
To determine the replication history of DS-B-lymphocytes by KRECs in relation to somatic hypermutation.
Objective: To analyze in more detail the complement activation and regulation and especially the functional CFH activity following three types of interventions in patients known with HUS and correlate these to clinical findings. The three…
To analyse which allergens within cow's milk, peanut or nuts are most potent in activation of T cells and basophils.
The aim of the project is to test BS6.890C in the prophylactic transplant model of psoriasis.
To collect demographic, clinical, therapeutic, microbiotic and imaging data in patients with JIA, to build a repository, to find novel biomarkers and to construct computerized models to predict the prognosis in children with JIA af the time of…