15 results
To study patients with clinically suspect arthralgia in order to 1) develop diagnostic/prognostic markers (a. markers of systemic and b. local inflammation as well as c. autoantibodies) for the development of RA 2) to improve the mechanistic…
The first aim of this study is to use an in vitro approach using patient's derived material to accurately and rapidly predict the optimal therapeutic approach that will predict a good clinical response in individual patients…
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease&…
To evaluate in SSc patients with low risk for disease progression 1) whether assessment in an outpatient clinic setting is an acceptable alternative for evaluation in the Care Pathway. Outcome parameters we will evaluate include 1) health care…
Determination of the (cost)effectiveness of the replacement of the expensive, risky and time-consuming food challenge test bythe Basophil Activation Test (BAT) for the diagnosis of an IgE-mediated cow*s milk allergy in children.
The primary objective of this study is:- to measure the effect of the VR program Reducept on the NRS pain score in patients with inflammatory arthritis with chronic pain despite low disease activity.The secondary objectives are:- to measure the…
Primary objective1. The primary aim of the study is to answer the question whether specification of a positive direct antiglobulin test and/or red blood cell autoantibody specification is correlated with the clinical course in patients with AIHA.…
Allergen immunotherapy (AIT) is currently performed with aluminum hydroxide-adsorbed allergen extracts. This approach is effective, but requires a long burdensome treatment protocol with a relatively high frequency of allergic side-effects…
The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…
To assess the effect of adding a tapering decision aid on a dynamic flare prediction model to disease-activity-guided dose optimisation (DGDO) on the incidence of flares and medication use.
Primary objectives: To develop and internally validate a novel and interpretable machine learning model for detecting flare in PsA patients using integrated accelerometer data, keystroke dynamics and screen time metrics (i.e., digital…
Primary objective is to study the antibody immune response to routine vaccinations in very preterm infants (GA<32 weeks). Secondary aim is to study the immune system more extensively using flow cytometry, ELISA and single cell…
To answer the following questions: 1. Who are the patients that need to be revaccinated?2. How many vaccinations are needed to restore SARS-CoV-2 immunity?3. Can the number of vaccinations needed to restore SARS-CoV-2 immunity be predicted?To…
We want to remap the entire bacterial ecosystem in the gastrointestinal tract of patients with lgA nephropathy after a period of roughy two years, in order to gain insight into the processes that may play a role in the development and progression…
Primary To evaluate the prevalence of specific immune cell subsets in a range of IMID dermatologic disease patients, both between diseases and compared to healthy volunteers Secondary To evaluate the variability in specific immune cell…