185 results
Primary Objective: To determine for a series of drugs frequently used perioperatively the maximal non irritative concentration in intracutaneous skin testing in healthy volunteers. Secondary Objective(s): To compare the percentage/number of positive…
Conditions that promote IL-10 producing B cells in humans are still ill defined. In this project our aim is to investigate the frequnecy of IL-10 producing B cells in healthy volunteers. Next, we aim to compare this to the frequency of IL-10…
To evaluate the efficacy and safety of a SCIT-treatment with a mutant recombinant fish-parvalbumin (mCyp c1) quantified in mass units and formulated in a solution with alum, in subjects with fish-allergy.
Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…
Primary Objective: Pilot study to identify the optimal patch test concentration for detecting contact allergy to ME-PPD in subjects with a proven contact allergy to PPD, who may be allergic to ME-PPD. Hypothesis: In this study subjects will be…
The primary objective is to evaluate whether 2.5 µg VD3 analogue (Zemplar® * Abbvie) in multiple subcutaneously administered doses induces a more favourable (read: anti-inflammatory) systemic immune modulation both in general parameters and allergen…
Primary Objective:The primary objective of this study is to test the feasibility of methods and procedures prior to performance of a full-scale research project.Secondary Objective(s):The secondary objectives of this study are to determine whether…
To study the immunomodulatory effects of non-digestible oligosaccharides using peripheral blood mononucleated cells isolated from blood of healthy controls and patients with peanut or cow*s milk allergy.
- Establashing the percentage of patients within a population allergic to house dust mite and/or crustaceans, that can get an allergic reaction from consuming mealworm.- Establashing the risk of sensitization and allergy by handling mealworms and…
The aim of this pilot study is to establish Th1/Th2/Th17 patterns in healthy controls by analysing cytokine concentrations in nasal fluid (nasal wash and cotton wool method), saliva and blood. This will be done in order to give an estimation about…
To determine the prevalence and severity of ASA-related allergic reaction in SM patients.
The primary objective is to set-up a well-defined sandwich ELISA method to measure the levels of Ara h6 in blood after peanut consumption.
Primary objective: To evaluate the efficacy of dupilumab, compared with placebo, for reducing the use of maintenance oral corticosteroids (OCS) in patients with severe steroid-dependent asthma.Secondary objectives:To evaluate the safety and…
are there differences in levels of IgE and sub-classes, TARC ,light chain IgG and titers against vaccins HiB and Tetanus between children who received as infant a formula with or without pre-biotics ?
To show that in eosinophilic oesophagitis gastro-oesophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic cells activates…
The major research objective is to prove that the consumption of plant stanol ester enriched yogurts can improve immune function in vivo in asthma patients
With this project we aim to determine the efficacy of anti-IL-5 treatment (mepolizumab) on virus-induced exacerbations in allergic asthma patients.Specific research questionsDoes IL-5 neutralisation:1) reduce the inflammatory response (T cell…
Primary objective:To investigate the effects of the three investigational products (1.Citrus e fructibus / Cydonia e fructibus as a whole, single preparations 2. Citrus e fructibus and 3. Cydonia e fructibus) on the changes in SAR related…
To analyze whether the sensitization profile towards hazelnut, peanut and birch pollen and their major individual allergens can be used to predict whether the hazelnut allergy is associated without/with mild clinical symptoms or severe clinical…
Objective: To establish the effect of perinatal probiotics on the prevalence of allergic disease at the age of 5 or 6 years.