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A randomized, double-blind, placebo-controlled study to compare the immune effects of multiple doses of vitamin D3 in patients with allergic rhinitis/rhino-conjunctivitis caused by birch pollen and in healthy control subjects.

The primary objective is to evaluate whether 2.5 µg VD3 analogue (Zemplar® * Abbvie) in multiple subcutaneously administered doses induces a more favourable (read: anti-inflammatory) systemic immune modulation both in general parameters and allergen…

FAST * Food Allergy Specific ImmunoTherapy
A multinational phase IIb study to investigate the efficacy and safety of subcutaneous immunotherapy with a modified fish- parvalbumin given in single rising and maintenance doses to subjects allergic to fish

To evaluate the efficacy and safety of a SCIT-treatment with a mutant recombinant fish-parvalbumin (mCyp c1) quantified in mass units and formulated in a solution with alum, in subjects with fish-allergy.

Diagnostics and mechanisms of titanium allergy

Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…

A novel class of regulators: the potential of IL-10 producing B cells in decreasing allergic inflammation in asthmatic patients.

Conditions that promote IL-10 producing B cells in humans are still ill defined. In this project our aim is to investigate the frequnecy of IL-10 producing B cells in healthy volunteers. Next, we aim to compare this to the frequency of IL-10…

Effects of Single Dose of Bilastine 20mg on Flying Ability in Healthy Volunteers Under Conditions of Simulated Cabin Pressure

Objective: The response over time on daytime alertness and performance will be assessed following a single oral dose of bilastine 20 mg in healthy volunteers performing flying ability tests in a hypobaric chamber with an ambient pressure of 75.2 kPa…

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Dupilumab in Patients with Severe Steroid Dependent Asthma

Primary objective: To evaluate the efficacy of dupilumab, compared with placebo, for reducing the use of maintenance oral corticosteroids (OCS) in patients with severe steroid-dependent asthma.Secondary objectives:To evaluate the safety and…

Aspirin provocation of patients with Systemic Mastocytosis

To determine the prevalence and severity of ASA-related allergic reaction in SM patients.

Assessment of the risk of foodallergy from mealworm consumption

- Establashing the percentage of patients within a population allergic to house dust mite and/or crustaceans, that can get an allergic reaction from consuming mealworm.- Establashing the risk of sensitization and allergy by handling mealworms and…

Training food-allergic patients to use their epinephrine auto-injector: a pilot study

Primary Objective:The primary objective of this study is to test the feasibility of methods and procedures prior to performance of a full-scale research project.Secondary Objective(s):The secondary objectives of this study are to determine whether…

Nutrition-based approach to support antigen-specific immunotherapy in subjects with cow's milk or peanut allergy

To study the immunomodulatory effects of non-digestible oligosaccharides using peripheral blood mononucleated cells isolated from blood of healthy controls and patients with peanut or cow*s milk allergy.

A randomized, double-blind, placebo-controlled, parallel group study evaluating efficacy and safety of QAW039 in the treatment of patients with moderate to severe atopic dermatitis (CQAW039X2201)

Primary objective: To evaluate the efficacy of once daily doses of QAW039, as measured by EASI after 12 weeks of treatment, relative to placebo, in adult patients with moderate to severe AD. To evaluate safety and tolerability.Secondary objectives:…

A double blind randomized placebo controlled study on the efficacy of intralymphatic immunotherapy in the treatment of grasspollen induced allergic rhinitis.

In this study we will compare the effect of intra nodal allegen injection with grass pollen to the intra nodal injection with placebo on symptome scores of allgic rhinitis (hay fever) in grass allergic patients.

Individually tailored Dietary treatment of Eosinophilic oesophagitis in Adults

To demonstrate that food elimination therapy based on component-resolved diagnostics is an effective and acceptable treatment for EoO patients.

Study on IgE Memory B cells in Allergic disease

We wish to study the absolute numbers, ratio and phenotype of CD27+IgE+ and CD27-IgE+ memory-B-cells in blood of atopic children who suffer from proven IgE-mediated asthma/hay fever, atopic dermatitis or food allergy and compare these with healthy…

Cross-sectional study on determinants of contact dermatitis on the hands of construction workers: etiologic studies and development of a diagnostic tool

Primary objective is to determine the actual occurrence of and risk factors for OCD on the hands of Dutch construction workers.With these new insights into the risk factors for OCD, we aim to develop 1) a new diagnostic tool to be used by…

Efficacy and tolerability of Citrus/Cydonia comp.® solution for injection in patients with grass pollen seasonal allergic rhinitis:
Randomised, double-blind, placebo-controlled comparative clinical trial with three parallel treatment groups

1. Clinically relevant reduction of symptom severity by use of Citrus/Cydonia comp. subcutaneous injections 2. To examine the use of rescue medication in the three groups, 3.safety of treatment

A Single Dose Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic Rhinitis Patients Challenged Intranasally with Allergen Extract

Primary objective: to assess the inhibition of allergic responses of a single dose of subcutaneously (SC) administered REGN1908-1909 as measured by total nasal symptom score (TNSS), visual analog scale (VAS) nasal symptoms score, and peak nasal…

Clinical follow up of EuroPrevall birt cohorts
A part of Integrated approaches to Food Allergen and Allergy Risk Management consortium study

To trace new onset of food allergy and clinical evolution of already established food allergy, determining frequencies and patterns of tolerance development. Influence of environmental and behaverioural factors will be investigated.

Evaluation of Pharmacokinetics, Relative Bioavailability, and Safety of PA-101 in Healthy Subjects, Patients with Systemic Mastocytosis, and Patients with Allergic Asthma

To evaluate the plasma pharmacokinetic properties and safety of the research medication in healthy volunteers and in Patients with Systemic Mastocytosis and Allergic Asthma.

Integrity of the Mucosa: effect of Amino acid formula on Gastrointestinal tract epithelium
in adult Eosinophilic esophagitis patients

Primary: To demonstrate that a liquid Neocate product (elemental nutrition) study decreased esophageal eosinophil count to less than 15 eosinophils per high-power field in adult patients with eosinophilic esophagitis.Secondary: To study the effect…