184 results
Determination of the (cost)effectiveness of the replacement of the expensive, risky and time-consuming food challenge test bythe Basophil Activation Test (BAT) for the diagnosis of an IgE-mediated cow*s milk allergy in children.
Primary objective:To investigate the dose - (clinical) response relationship and therapeutic window of biologics in the treatment of CRSwNP.Secondary objectives:- To investigate the effect of biologics on the sensibilisation pattern of specific IgE…
• To evaluate the safety and tolerability of THB001 in cold induced chronic urticaria patients
What is the clinical- and cost-effectiveness of early low-dose oral immunotherapy aimed at long-term tolerance induction in children under the age of 30 months with an established food allergy compared to routine care?What is the effect of early low…
1. Are the results of the skin prick test (SPT) performed with homemade extracts and the prick-to-prick test (PTP) with fruit and vegetables comparable?2. Is there a difference in sensitivity and/or specificity between the SPT and PTP with fruit and…
We aim to compare the outcome of open and double-blind placebo controlled food challenges in children suspected of having food allergy. Within the first non-inferiority study, the ALDORADO trial, we hypothesise that the open food challenge is…
To assess the effect of dupilumab on sleep, to evaluate the effect of dupilumab on additional patient reported sleep outcomes, on objective sleep assessment, asthma symptoms, long function and the safety of dupilumab.
The aim of this study is to compare results of sensitization measurements (positive or negative) in skin test and blood test, with new nutritional proteins in food-allergic patients.
The primary objective of the study is to evaluate the efficacy of dupilumab on the lung function in patients with ABPA.The secondary objectives of the study are:• To evaluate the effects of dupilumab on exacerbations in patients with ABPA • To…
The primary objective of this study is to demonstrate clinical benefits of prolonged consumption of plant stanols (delivered via plant stanol esters) in asthma patients. The secondary objectives are to evaluate the mechanisms via which plant stanols…
Primary Objective:Identify trends in the incidence of skin contact allergy with particular reference to fragrance materials that have not hitherto beentested on a systematic basis.Secondary Objective(s):A subsidiary objective is to gather data on…
Primary Objectives• To evaluate in vivo complement activation after first-time treatment with paclitaxel, liposomal doxorubicin (Caelyx) or other complement-reactogenic compounds• To evaluate ex vivo complement activation after incubation of predose…
The primary objectives of the study by study part are:Part A:To determine the treatment effect of dupilumab compared with placeboin adult and adolescent patients with EoE after 24 weeks of treatment as assessed by histological and clinical measures…
This is an exploratory study with two objectives:1. To investigate whether modification of allergenic milk and peanut proteins or peptides thereof with glycans can support oral tolerance induction by altering the antigen-specific T cell response…
Identify phenotypes using clinical characteristics and non-invasive biomarkers that can guide treatment.
The primary objectives are:*To describe patient characteristics, treatment patterns and the burden of illness over time for individuals in clinical practice with a diagnosis, or suspected diagnosis,2of asthma and/or COPD. Data will be described for…
To assess whether ADRB2 genotype-guided asthma treatment in children with persistend athma symptoms despite ICS treatment leads to better asthma control compared to non-genotype-guided asthma treatment.
Upregulation of the inflammatory response in skin of patients with atopic dermatitis, psoriasis or cutaneous LE coincides with the expression and secretion of a distinct set of proinflammatory markers, including cytokines, chemokines and soluble…
The primary objective of this study is to determine if medication allergy sensitization can be accurately determined through a laboratory test with a patients* blood sample. The secondary objective is to develop a laboratory assay that can be…
Primary: Evaluate whether quantification of functional IgE on basophils of food allergic patients can omit the need for food challenge tests to diagnose severity and threshold of the allergic reaction. Secondary: Evaluate whether numbers of…