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Walking fatigability and the relation to walking economy and walking quality and the impact on social role participation and daily life activity in persons with Multiple Sclerosis.

The main objective is to investigate the association between walking fatigability during the 6 minute walking test (6MWT) and walking economy in pwMS who are able to walk independently. Secondary objectives are to investigate the role of I. walking…

The interaction between arthritis and the orofacial tissues - prediction and prevention of rheumatoid arthritis.

The primary objective of this study is to assess the prevalence of Temporomandibular Joint Disorders in (1) rheumatoid arthritis (RA) patients, (2) individuals at increased risk of RA, and (3) a control group without autoimmune diseases and to…

Immunological assessment of SARS-CoV-2 in IENIMINI cohort individuals with influenza like symptoms.

Primary objective: To evaluate, in a cohort of non-tested individuals who reported flu-like symptoms during the COVID19 epidemic in the Netherlands (March-November), the seroprevalence of COVID19 in patients with an IMID, with or without…

PsA digital phenotyping and inflammation drivers study

Primary objectives:To develop and internally validate a novel and interpretable machine learning model for detecting flare in PsA patients using integrated accelerometer data, keystroke dynamics and screen time metrics (i.e., digital biomarker) to…

A phase 1, open-label, non-randomized, 2-period, fixed sequence study to investigate the absorption, metabolism and excretion of [14C-PF-04965842] and to assess the absolute bioavailability and fraction absorbed of PF-04965842 in healthy male subjects using a 14C-microtracer approach.

The purpose of the study is to investigate how quickly and to what extent PF 04965842 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). A small part of the PF 04965842 to be…

MS Self - A study on the validity, sensitivity and user experience of new mobile selfmonitoring devices voor people with Relapsing Remitting Multiple Sclerosis

Technological developments such as smartphones and consumer wearable devices (i.e. the Fitbit) provide novel opportunities for selfmonitoring of people with chronic diseases.Here, we aim to gain insight into the use of these technologies for studies…