49 results
To determinate the efficacy and safety of golimumab in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study.
To evaluate the efficacy and safety of nilotinib in spondyloarthritis
PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…
In the present study we will evaluate the standardized care protocol developed in our outpatient clinic, intended to guide counselling for medication use prior to pregnancy. This protocol guides treatment decisions based on disease activity,…
The aim of our project is in-depth characterization of the microbiota components both adjacent to and within the mucosa in patients with IBD, by applying novel high-throughput analysis technology in a global description strategy approach.…
To determinate the efficacy and safety of certolizumab pegol in rheumatoid arthritis patients in daily clinical practice during 48 months. In addition, the effect of treatment with certolizumab pegol on the lipid profile will be monitored during…
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
ln this study effect of 3 novel compounds on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to one registered drug, namely Remicade(R).
1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.
The present proposal seeks to compare the cardiovascular and gastrointestinal safety and effectiveness of a strategy of initial randomisation to treatment with the selective COX-2 inhibitor celecoxib or to *usual-care* with their current non-…
To assess the efficacy and safety of treatment with tocilizumab versus adalimumab, both in combination with methotrexate, in patients with moderate to severe active rheumatoid arthritis who have had an inadequate efficacy response to treatment with…
To determine the presence of ACPAs in patients with generalized severe periodontitis. Second objective is to assess RA development of ACPA positive periodontitis patients in the future.
The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…
Primary objective: to study the effect of faecal transplantation in a phase II randomised placebo controlled design on simple clinical colitis activity index (SCCAI) and endoscopic Mayo score. Secondary objective: to study intra individual changes…
The primary objective is:* to assess the accuracy of DCE-MRI in detecting joint inflammation as compared to physical examination in the evaluation of different stages of disease activity in JIA patients The secondary objectives are:* to evaluate the…
1. To determine, in patients treated with TNF α blockers and living in the Q-fever endemic area, the prevalence of antibodies against C. burnetii and the prevalence of chronic Q fever.2. To assess other determinants in this group of patients which…
The aim of the study is to evaluate the efficacy and safety of three IV treatment regimens of sifalimumab in adult subjects with chronic, moderately-to-severely active SLE with an inadequate response to SOC SLE (Standard Of Care treatment for SLE).…
The primary efficacy objective is to determine the effect of NCAP on the clinical signs and symptoms of rheumatoid arthritis as assessed by the 28 Joint Disease Activity Score (DAS28).The secondary efficacy objectives are to determine the effect of…
In previous projects a number of compounds were tested that had a positive effect in the transplant model of psoriasis. However, it proved difficult to prepare formulations that were stable enough to use in clinical studies. A new compound (CD07813…
ln this study the effect of 2 novel compounds on the development of psoriasis in the humanized mouse model is investigated. The efficacy is compared to one registered drug, namely Stelera.