24 results
The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…
In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.
To determine the replication history of DS-B-lymphocytes by KRECs in relation to somatic hypermutation.
The primary objective of the study is to compare the efficacy of intravenous immunoglobulin product with the efficacy of antibiotic treatment in patients with recurrent respiratory infections and IgG-subclass deficiency and/or selective anti-…
To characterize the interaction between the genetic background, the microbiome, and the immune responses in patients with diabetes type 1, both cross-sectional and over time, and to identify the disturbances in this interaction.
We propose to investigate the health related quality of life (HRQoL) in childhood survivors of refractory GvHD who have been treated with mesenchymal stem cell transfusions. This will be a multi center study involving the Division of Clinical…
To assess the prevalence of HIV, hepatitis C and B, and (related) risk behavior among hard drug users in care at Mondriaan carecentre for addiction in Heerlen.
Objective of this study is to determine the turnover of leukocyte populations in health (young, old) and how this compares to situations in which the immune system is disturbed ((HIV-1 infection, HSCT, thymectomy).
Primary: Dose finding for a twice daily regimen for PSZ as prophylactic treatment in children with CGD, based on the exposure to PSZ measured by PSZ trough levels.Secondary:To determine the tolerability of PSZ as prophylactic treatment in children…
Primary objective: The primary objective of the study is to determine the effects of BCG-vaccination on the immune response induced by subsequent influenza vaccination in healthy volunteers. This will be determined by measuring the Th1/Th2 response…
Primary: To provide insight in the prevalence of diagnosed cases of IgG-subclass and/or antipolysaccharide antibodydeficiency in Dutch children. Secondary: To provide insight in the diagnostic process, the clinical presentation, the therapies used…
Study whether chloroquine as comedication results in a better respons on Hepatitis B vaccination in non-responder dialysis patients.
Clarifying the qualitative and quantitative aspects of the T cell response targeting and controlling polyomavirus BKV.
In this study we want to apply heavy water labelling to investigate how ageing affects the dynamics of different leukocyte populations.The main objectives of this study are:(A) to get more insight in the dynamics of an ageing immune system, in order…
In this study we intend to give the label "deuterium" to individuals as heavy water, to determine the turnover parameters of diverse leukocyte populations in health (young adults, healthy seniors of 60 years and older, healthy individuals…
Measuring the stability (and thereby half-life) of TRECs.
Primary Objective: The primary objective is to analyse the humoral and cellular immune response to influenza vaccination in PHTS individuals.• Is the immune response to seasonal influenza vaccinations impaired in PHTS?• Do characteristics in humoral…
Objective: To show the protective value and to measure cost effectiveness of higher Ig dosing on progression of lung disease in PAD.
The primary objective of the study is to provide natural history data onpatients with P-CID, irrespective of whether they undergo HSCT or not.The goals are to determine survival, the frequency of severe eventsand quality of life 5 years after study…
The primary goal is to evaluate the presence and type of skin disorders in patients with a PID. Secondary objectives are to determine the presence of S. aureus on the lesional skin and/or nose in patients with a PID and to evaluate the presence of…