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Analysis of immunological and genetic signatures in pediatric inflammatory bowel diseases

In this study it is aimed to investigate the genetic and immunological causes of VEO-IBD in order to improve diagnostics and therapies for patients with this intractable disease. In an explorative approach, state-of-the-art genome-wide screenings on…

NATURAL KILLER CELL PHENOTYPE IN UNEXPLAINED RECURRENT MISCARRIAGES

The main goal of this study is to analyse NK cell phenotype in women with unexplained recurrent miscarriage in relation to their physical health.

Effects of nicotinamide riboside (vitamin B3) in patients with Ataxia Telangiectasia

The purpose of this research is to investigate whether treatment with nicotinamide riboside (vitamine B3) has a positive effect on the disease course of patients with ataxia telangiectasia.

Dissection of the blood B cell compartment in affected and non-affected family members of patients with Common Variable Immunodeficiency (CVID).

Investigation of the blood B cell compartment in family members of CVID patients (with and without a CVID family history) to identify or exclude B-cell defects and to improve our insight into a potential familial background of CVID.

PHASE I/II CLINICAL TRIAL OF AUTOLOGOUS HEMATOPOIETIC STEM CELL GENE THERAPY FOR RAG1-DEFICIENT SEVERE COMBINED IMMUNODEFICIENCY

This study has been transitioned to CTIS with ID 2023-510204-50-00 check the CTIS register for the current data. Primary: The main objectives of the study are to demonstrate feasibility and safety of gene corrected autologous CD34+-selected…

Response to pneumococcal polysaccharide vaccination in healthy adults

Primary Objective: • To develop new criteria for the interpretation of the IgG response to pneumococcal polysaccharide vaccination using serotype-specific normal values.Secondary Objectives: • To develop criteria for the interpretation of the IgG1,…

Impact of Alemtuzumab exposure on immune reconstitution, autoimmunity, risk of infection, chimerism and Graft-versus-Host Disease in children with non-malignant diseases undergoing allogeneic stem cell transplantation. ARTIC International Multicenter Observational Study.

Primary objectiveTo evaluate current clinical practice and develop a population based Campath® (Alemtuzumab) pharmacokinetics model for predicting total Alemtuzumab exposure after i.v. administration before allogeneic stem cell transplantation in…

Single-cell analysis of somatic mutations to understand and improve blood formation after hematopoietic stem cell transplantation

We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.

Long-term outcomes in immunologically low-risk kidney transplant recipients using tacrolimus.
Extension study of: Tacrolimus monotherapy in immunologically low-risk kidney transplant recipients: a pilot randomized-controlled study.

This study has been transitioned to CTIS with ID 2024-513394-42-01 check the CTIS register for the current data. To assess long-term outcomes in low-immunological risk renal transplant patients beyond one year after transplantation using tacrolimus…

HIV-1 Envelope Sequence Diversity Within the Latent Reservoir in HIV-1 Infected Individuals Initiated on Antiretroviral Therapy (ART) During Acute and Chronic Infection.

To determine the frequency of R5-tropic N332+ viral isolates present within the latent reservoir while on suppressive ART.

Registering the immune response to an influenza vaccination challenge in PTEN Hamartoma Tumour Syndrome

Primary Objective: The primary objective is to analyse the humoral and cellular immune response to influenza vaccination in PHTS individuals.• Is the immune response to seasonal influenza vaccinations impaired in PHTS?• Do characteristics in humoral…