67 results
Allogeneic hematopoietic stem cell transplantation is often complicated by graft versus host disease (GvHD) causing high morbidity and mortality. Loss of gutmicrobial diversity is a risk factor to develop GvHD. We will test the hypothesis that…
Primary Objective: To objectify the innate immune response to acute and prolonged exercise and get insight in this response over time (hours). Secondary Objective(s):- Investigate the nature of the post-exercise leukocytosis- Which leukocytes appear…
In this study we aim to elucidate effects of dietary sodium intake on:1. Microcirculation by studying the capillary network during high and low sodium conditions.2. Adaptive and innate immune system by studying circulating T-lymphocyte…
1. To determine if zinc supplementation in AMD patients has a direct measurable effect on the complement system explaining the mechanism through which this substance exerts its influence on AMD progression.2. To determine whether this proposed…
Our hypothesis is that antibodies of COPD patients contribute to inflammatory processes leading to cell death, and that the level of cytotoxicity differs between COPD patients and healthy volunteers. The prime aim is to detect differences in…
Identifying the factors and underlying mechanisms involved in the pathogenesis of immune paralysis in trauma patients. Mapping the time-course of immune paralysis in trauma patients.
Primary Objective: to investigate the effect of rosuvastatin 20 mg qd on subsequent immune activation markers in treatment-naïve HIV-patients: circulating LPS (LAL assay), TLR mRNA expression in whole blood, circulating IL-6, D-dimer, hsCRP, CD38…
In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…
To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.
The objective of this study is to assess potentially new and unique biomarkers that will be specific to patients with HIDS as surrogate outcomes for eventual larger, cohort-controlled clinical studies. Our longitudinal design in a small pilot group…
1. To describe the development of the nature of the immune system in early life in a profile of cytokines, chemokines and adipokines. 2. To evaluate less invasive methods like the use of saliva or less demanding methods like the use of dried bloods…
Primary Objective: The main objective of this study is to analyse the effects of pregnancy on levels and percentages of CD8 cell subsets in peripheral blood both during and after pregnancy.
The study is a diagnostic study for the diagnostics of sarcoidosis, in where a new, endo-sonographic procedure is compared to the current, bronchoscopic method.The objective is to assess the accuracy, safety and patient tolerance of endo-sonography…
To investigate the relation between a known genetic variation in a set of selected genes involved in the recognition of microorganisms and inflammation and the frequency of respiratory tract infections in a group of children with DS.
The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.
We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…
We aim to define the role of systemic, low grade, chronic inflammation in the development of sarcopenia and therefore study patients with rheumatoid arthritis and patients with osteoarthritis as controls, on cellular and functional level. Until now…
Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.
In previous studies we have identified specific receptor and surface protein expression profiles on neutrophils. Some of these profiles point at partially refractory neutrophils. In the current NERTHUS study we have seen that circulating neutrophils…
Primary objective: To explore whether prolonged moderate alcohol consumption affects in vivo cytokine response after a low dose of LPS in young, normal-weight men.Secondary objectives: To explore whether prolonged moderate alcohol consumption-…