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Cerebral perfusion during neonatal cardiac surgery: Can we improve outcome?

In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…

Sarcopenia in patients suffering from rheumatoid arthritis and osteoarthritis, a pilot study.

We aim to define the role of systemic, low grade, chronic inflammation in the development of sarcopenia and therefore study patients with rheumatoid arthritis and patients with osteoarthritis as controls, on cellular and functional level. Until now…

In vivo effects of C1-esterase inhibitor on innate immune response during endotoxemia in human.

The primary objective is to investigate the effects of intravenous administration of C1INH in human volunteers on cytokine release (TNFa) during endotoxemia. The secondary objective is to determine the effect of administration of C1 INH on…

The effect of long-term olive-oil based parenteral lipid use on immune functions: a patient-control study

To evaluate immune function and (the susceptibility for) oxidative damage under the influence of long-term olive-oil based TPN use in patients without an active underlying disease and compare this with findings in healthy controls

Effect of colostrum on immune function after intense strenuous exercise in well-trained cyclists.

The primary objective of this study is to evaluate the effect of colostrum supplementation on the immune response after intense strenuous exercise.The secondary objective is to study the effect of intense strenuous exercise - and its possible…

Release of endogenous ligands of Toll-like receptors type 4 during mechanical ventilation in surgical patients with healthy lungs

Primary objective is to show the presence of endogenous ligands of TLR4 in the lung of patients being mechanically ventilated in a standardised way with clinical parameters. Secondary objective is to investigate the amount of endogenous ligands of…

Differential modulation of dendritic cell (DC) maturation and associated signal transduction as the pivotal events for leprosy spectral pathology

Overall aim: To study the influence of M.leprae antigens on differentiation and maturation of DCs and to identify M.leprae antigens, receptors on antigen presenting cells and signaling pathways which play a role in leprosy pathology. Main objective…

Bosentan (Tracleer®) in patients with Behçet*s disease: a Pilot Study.

· To determine therapeutic efficacy of Tracleer in patients with active Behcet disease. Furthermore:· To study cytokine and immunological patterns and ET-1levels in those patients.

The role of genetic variations in type I Interferons related to respiratory tract infections in Down Syndrome children.

The main objective is to identify a difference in mRNA expression level of IFN and IFN related genes between Down Syndrome children and a control group of healthy children (siblings). The secondary objective is to identify a relationship between…