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Study to evaluate the effects of intravenously administered LPS on the bone marrow immune cell compartment in healthy male volunteers

• To investigate the (early) effects of i.v. LPS challenge model on the bone marrow and whole-blood immune compartments, by: o evaluating the immune cell subtypes present within the myelo- and lymphopoiesis in the bone marrow niche before and after…

Long-Term Follow-Up of Patients who have received an Autologous Antigen-Specific Chimeric Antigen Receptor T Regulatory Cell Therapy (TX200-TR101) in a prior clinical study.

This study has been transitioned to CTIS with ID 2024-512580-31-00 check the CTIS register for the current data. PrimaryTo evaluate the long-term safety and tolerability of TX200-TR101 up to 15 years post-TX200-TR101 infusion/baseline.SecondaryTo…

Hyperbaric Oxygen Therapy for Pyoderma gangrenosum As a New Treatment Strategy

To investigate the therapeutic efficacy and feasibility of hyperbaric oxygen (HBO) in addition to standard wound care in patients with pyoderma gangrenosum wounds.

Clinical investigation of the safety of the MediSieve Magnetic Haemofiltration System in healthy volunteers.

To determine safety of the MediSieve Magnetic Hemofiltration System in healthy volunteers.

A Randomised Open-Label Trial of Early, Very High-Titre Convalescent Plasma Therapy in Clinically Vulnerable Individuals with Mild COVID-19

To determine whether convalescent plasma collected from donors who have recovered from COVID-19 and who have a very high titre of anti-SARS-CoV-2 antibodies reduce the risk of hospitalization or death due to COVID-19 in patients with early symptoms…

First-in-human, randomized, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic effects of Apta-1.

Part ATo evaluate the safety and tolerability of single and split intravenous doses of Apta-1 in healthy volunteers.Part BTo evaluate the safety and tolerability of split intravenous doses of Apta-1 after LPS infusion in healthy volunteers.

the role of risk factors on the host-pathogen interactions in melioidosis

This study aims to delineate the alterations in leukocyte function during ex-vivo host-pathogen interactions. These data will be correlated with several factors such as coexisting comorbidities (e.g. diabetes) and functional defects analyzed using…