52 results
To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the response of infection treatment of a prosthetic joint infection.
Primary Objective: To determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxisSecondary Objectives:• To determine the dose-dependent protective efficacy of NF135.C10 CPS-immunization against homologous…
To deliver proof of concept that antifungal prophylaxis with posaconazole in addition to standard of care (SOC) can reduce the incidence of IAA in ICU patients with severe influenza, in comparison with SOC alone.To assess differences in cytokine…
The primary objective is to evaluate superiority of pimodivir (Pi) in combination with standard-of-care (SOC) treatment (tmt) compared toplacebo in combination with SOC treatment, with respect to the time to resolution of influenza-related symptoms.
The aim of this study is to evaluate and describe the PK of fosfomycin in individuals receiving oral treatment with multiple dosages of fosfomycin for recurrent and/or complicatedurinary tract infection. The results of this study will be used to…
The primary objective is to establish the non-inferiority of treating a symptomatic urinary tract infection in patients with a long-term indwelling catheter for 5 days, as compared to the standard duration of 10 days of therapy. Secondary objectives…
To assess the impact of FMT on detectable intestinal carriage (by stool culture) of VRE in a 12 month follow-up period.
We plan to conduct a large, pragmatic, multicentre, randomised non-inferiority trial to determine whether the use of intraoperative dexamethasone, a widely used antiemetic in perioperative medicine, is associated with an unacceptable increased risk…
1. To estimate the incidence and severity of fungal infections during anti-Th17 mAb therapy2. To characterize the determinants (clinical, immunological, mycobiome/microbiomeand genetical) for developing fungal infections during anti-Th17mAb therapy…
The primary aim of our *Imaging of Fracture-related Infections trial (IFI trial)* is to assess the diagnostic accuracy of all commonly requested medical imaging techniques (WBC scintigraphy, FDG-PET/CT and MRI). The secondary aim is to establish…
The primary objective of this study is to compare the safety, overall tolerability, and virologic response of BCV vs. SoC (i.e., investigator-assigned therapy) for the treatment of AdV infection in high-risk pediatric allogeneic HCT recipients. A…
To clarify the pathophysiological genetic pathway of the association between C. burnetii and NHL
Primary objectives: 1. . To study prevalence of NASH in unselected HIV-monoinfected patients assessed by Fibro scan. Secondary objectives:2. To identify risk factors for NASH in HIV infected patients compared to HIV-positive patients without NASH. 3…
We aim to validate cellular tests to determine their value in diagnosing LB, as well as to describe the potential added value of these tests in the setting of a specialized Lyme center.
The primary goal is to evaluate the presence and type of skin disorders in patients with a PID. Secondary objectives are to determine the presence of S. aureus on the lesional skin and/or nose in patients with a PID and to evaluate the presence of…
Primary objective: To determine the effect of obesity (BMI *35 kg/m2) on the pharmacokinetics, including oral bioavailability of fluconazole.Secondary objective: To develop an optimal dosing regimen for obese patients.
(1) To determine the presence of T. pallidum DNA as proxy for the infectiousness of peripheral blood, urethral, anal and pharyngeal mucosa in infectious syphilis. (2) To evaluate T. pallidum polymerase chain reaction test (Tp-PCR) to diagnose…
The objective of this study is to determine the incidence of chronic Q fever and seronegativity in vascular patients that were seropositive after the Dutch Q fever outbreak. Seropositivity can indicate a past resolved Q fever infection or chronic Q…
To validate and demonstrate reproducibility of the identified sepsis CR gene signature in participants from different age groups. The validation multicenter study will also lead to biomarker refinement of the original core set of 31 genes tailored…
Aim of the MIRRE pilot study is to determine how much the primary inoculation dose of diarrheagenic E. coli should be lowered in order to result in a reduced protective response upon a secondary infection.