59 results
2.1 HypothesisPrimary infection with Mtb induces temporal changes in the innate immune system, known trained innate (aangeboren) immunity, and the extent of trained innate immunity influences subsequent activation of adaptive (verworven) immunity.2.…
To determine the efficacy of a filter-based depletion of RBC-pathogen complexes by a single apheresis tretatment in patients with sepsis.
MOODSTRATIFICATION is a large, multi-center international study supported by the EU. Workpackage 3 aims to establish a proof-of-concept for a succesful therapy-stratification model for use in patients with a moderate to severe depressive episode.…
Whooping cough is very contagious. Earlier research shows that family members of a child with whooping cough are often also infected with the pertussis bacterium. However, not everyone who is infected with the bacterium develops symptoms. In this…
Primary Objective: To assess the effect of early extra measles immunization on the humoral immunity against measles 6 years after MMR-1 at 14 months of ageSecondary Objective(s): •Determine the effect of early extra measles immunization on the…
Primarily, we aim to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance. To increase the chances of success, the genomic and transcriptomic data obtained in vivo will be integrated with data obtained by a…
To study the effect of sweetener oral rinses on the oral microbiome composition.
Aim of the study:To investigate the role of the CD200/CD200R axis on the responsiveness of whole blood, peripheral blood mononuclear cells (PBMCs) and neutrophils to a proinflammatory challenge in the immunoparalysed state in sepsis patients.…
The aim of this study is to determine the optimal anatomical sample site for the evaluation of CT viability by comparing the total CT load (as determined by route NAAT) and viable CT load (by V-PCR) from different anatomical sample sites.
The aim is to check on current virology values (viral load (HBV DNA) and quantified HBsAg, HBcrAg, HBV RNA) to clarify if a complete return to baseline has occurred or if decreased values are still observable in patients that participated in part B…
Primary objective: To obtain insight into signature of immune responses triggered by a bivalent- or nonavalent HPV vaccination (three-dose schedule). Secondary objectives: To determine the most informative time-points to study different innate and…
To demonstrate that QIV-HD induces an immune response that is superior to the responses induced by QIV-SD for all 4 virus strains 28 days post-vaccination in subjects 60 to 64 years of age and in subjects 65 years of age and older.
To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…
Objective: - describe and monitor the molecular epidemiology of HCV in MSM in Amsterdam- determine HCV transmission networks in MSM- determine the factors associated with HCV transmission networks- determine role of HIV positive MSM who acquire…
The primary aim of the study of to investigate time and concentration of cefazolin above the MIC. The main secondary aim is to investigate influence of cardiac surgery and use of CPB on PK parameters of cefazolin. We aim investigate the new dosing…
*Premature infants and maternal pertussis immunization. Is second trimester vaccination beneficial?*
Our primary objective is to evaluate non-inferiority of anti-Pertussis Toxin (PT) IgG in term infants at 2m of age born of mothers having received a pertussis vaccine between 20-24w Gestational Age (GA) compared to a reference anti-PT IgG at 2m of…
Primary Objective: To prospectively compare outcomes of subjects with diabetic foot osteomyelitis treated with antibiotics targeted at culture results from bone biopsy (intervention group) versus therapy targeted at ulcer bed biopsy culture results…
Primary Objectives• Employ a systems biology approach to identify a set of candidate biomarkers (BM) in circulation and/or pathways & mechanisms that correlate with particular non-AIDS defining comorbidities (ie NASH, CVD) in HIV+…
The results of this research contribute significantly to the field of Travel Medicine, especially for elderly travelers who have been vaccinated with YF-17D at 60 years or older, and who are planning to visit a yellow fever endemic country in the…
The primary objective of this study is to evaluate the safety and tolerability of intramuscular administration of the HIV-1 envelope protein ConM SOSIP.v7 gp140 vaccine, adjuvanted with MPLA liposomes, in HIV-uninfected adults. The secondary…