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Observational multi-center, prospective study to develop a novel multi-parametric diagnostic model for hospitalized patients and patients on the Emergency Department presenting with lower respiratory tract infections and/ or sepsis.

To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

Long-term StaphyloCoccus aureus decolonizAtion in patients on home parentRal nutRition: a randomized multicEnter tRial.

To identify the most effective and safe long-term S. aureus carriage decolonization strategy in HPN patients. Ultimately this willlead to less antimicrobial resistance, less catheter removals and lower mortality rates. Also, other chronic…

Immunological factors of pain and infection in patients with burns

First, to explore relationships between immunological factors (cytokines and chemokines), psychological stress, and pain, controlled for infection. Second, to explore relationships between immunological factors (MBL), bacterial colonisation and…

Community Acquired Pneumonia: Outcome, Quality of Life and Immune Status

The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.

A Study Into The Diagnostic Properties Of A New Device For Rapid Bedside Testing Of Infection In Chronic Wounds: The INFACT 2.0 study

The primary objective of the study is to determine sensitivity, specificity, positive and negative predictive value of the enzyme analyses (myeloperoxidase, human neutrophil elastase and lysozyme) with wound biopsies as the gold standard.…

Understanding Q-detect: Coxiella burnetii exposure and the humoral and cellular immune response

(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and

The correlation between culture of the nasopharyngeal swab, the nose swab, swab from a handkerchief and a handkerchief directly in children with an upper respiratory tract infection

The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.

Multisite Near-infrared spectroscopy monitoring in newborn infants at risk of circulatory failure

The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…

Biomarkers in acute and chronic bacterial endobronchial infections in Cystic Fibrosis
A Pilot study

Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…

Molecular detection of the bacterial load as a diagnostic and monitoring tool for optimal antibiotic treatment in endocarditis

Primary objectives:- Evaluation of the value of mBL as a diagnostic tool for bacterial endocarditis.- Evaluation of the value of mBL as a monitoring tool during treatment for bacterial endocarditis.- To obtain data on the kinetics of mBL related to…

MBL and prediction of risk on chemotherapy induced febrile neutropenia in patients with a solid tumor.

To explore the association between MBL level at baseline and the incidence of febrile neutropenia.

Pilot study using Fluorine-18 labeled leucocytes in diagnosing infections.

The purpose of this study is to obtain an impression of the general image quality and clinical value of leucocyte PET/CT in visualizing infectious foci in the body.

Comparison of assays for Borrelia detection

To investigate the diagnostic properties of Borrelia immunoblots from various manufacturers and compare the diagnostic properties of different bands, and to validate the diagnostic value of B. burgdorferi PCR on blood and urine.

Comparison of novel assays for the molecular detection and quantification of bacteria in patients with bloodstream infections

To evaluate molecular assays for the detection and quantification of bacterial DNA in blood of patients with bacteraemia. Objectives are to determine the diagnostic performance of five molecular assays for the detection of bacteraemia in patients…

Immunogenetic, pharmacological and neurodevelopmental aspects of nosocomial sepsis and meningitis in preterm infants.

1. To identify and specify bacteria by using RT-PCR on blood and cerebrospinal fluid (CSF) in preterm infants, having nosocomial sepsis and meningitis.2. To compare RT-PCR (see aim 1) with the gold standard bacterial culture in preterm infants,…

Effect of procalcitonin-guided decision making on duration of antibiotic therapy in suspected early-onset neonatal sepsis: multicenter prospective randomized intervention study

1. To decrease the proportion of infants treated with antibiotics for > 48 - 72 hours with possible or unlikely infection, with unchanged outcome. 2. To reduce the duration of antibiotic therapy

Pre-hospital treatment of sepsis: reduction in mortality in severe sepsis.

To give answers to the following questions: 1) Will prehospital treatment with augmentin 1,2 gr v.v.reduce the mortality in patients with severe sepsis?2) What is the real percentage of septic patients who are suspected to have a severe sepsis in…

Follow-up after treatment of Neisseria gonorrhoeae infections, when and how is a test-of-cure to be included in routine? A prospective observational cohort study

The primary objective is: The minimum time in days after treatment for Ng to perform a TOC using NAAT and DNA PCR. Secondary objectives are: Time to clearance per infected location. Host and pathogen related factors associated with time to clearance…

Q Herpen II, Post outbreak screening in a Q fever high incidence area for late consequences of Q fever including chronic Q Fever.

This study will provide a robust estimate of the prevalence of C. Burnetii exposure and possible chronic Q fever among asymptomatic participants. This is important in order to assess whether population screening in a high incidence area is useful…

Changes in middle cerebral artery blood flow velocity during the early phase of fluid resuscitation in septic intensive care patients

Primary we aim to investigate whether the MCA blood flow velocity measured by TCD changes after initial fluid resuscitation in septic ICU patients, and secondly whether this MCA blood flow velocity has the ability to accurately predict fluid…