336 results
To determine the efficacy of oral fosfomycin in comparison to the standard of care oral ciprofloxacin, in the treatment of FUTI after initial empirical treatment with intravenous antibiotics.To describe the pharmokinetic profile of men treated with…
1) To establish associations between microbiome profiles and disease severity in patients with acute pancreatitis. 2) To establish associations between specific microbial shifts and infectious complications in the subgroup of patients with…
The primary objective is to determine whether implementation of a best-practice protocol focused on antimicrobial stewardship in Dutch hospitals is non-inferior compared to standard care on mortality and major complications in patients with acute…
The project will aim to quantify very long-term sequelae after childhood BM (~31 years after infection) on a wide range of functional outcome domains: neurocognitive functioning, behavioral and emotional functioning, health related quality of life,…
To investigate the influence of flucloxacillin treatment on CYP - and UGT substrate plasma concentration, to gain further understanding of potential clinically relevant drug-drug interactions with flucloxacillin.
To assess feasibility of self-administration of intravenous antimicrobial therapy in the Dutch context.
The primary objective is to investigate if a very short-course of antibiotics for cholangitis after adequate drainage is non-inferior with respect to clinical cure in comparison with a standard course of antibiotics.
To further study the mechanisms responsible for the Borrelia induced inhibition of antigen presentation and the impaired immuneresponse in Lyme disease pat¡ents, we would like to assess the immunological changes that occur in patients with a…
: Our aim is to evaluate whether the current flucloxacillin absorption test is able to adequately predict the absorption of flucloxacillin compared to an absorption test after switch to oral therapy, and identify co-variants in order to improve the…
To determine the effects of the CytoSorb hemoperfusion column on the development of immunoparalysis in a repeated human endotoxemia model, which is reflected by attenuated plasma cytokine levels during the second LPS challenge.
Primary Objective: To assess the efficacy and safety of faecal microbiota transfusion in female renal transplant recipients with intestinal carriage of extended-spectrum β-lactamase Enterobacteriaceae (ESBL-E) and/or carbapenemase producing…
To develop a pharmacokinetic (PK) model for the relationship between dosage, blood concentration and infection site concentration, estimating covariates to determine differences in antibiotic concentrations in synovial fluid, synovial tissue and…
The study*s primary objective is to collect a range of clinical specimens for assay development, qualification, and validation from participants with suspected Lyme Borrelia infection and/or Lyme disease. Secondary objective: To describe the…
Primary objectiveTo establish whether saliva samples could be used as an alternative for blood samples in the therapeutic drug monitoring for amikacin and flucloxacillin. To meet this objective, a PK mod-el will be developed for amikacin and…
Primary objective: The primary objective of this study is to investigate if taking methenamine hippurate reduce the need for antibiotic usage due to recurrent UTI (measured as the number of courses of antibiotics).Secondary objectives:to investigate…
To assess the efficacy of a single, oral, 3 grams (g) dose of zoliflodacin compared to a combination of a singleintramuscular (IM) 500 milligram (mg) dose of ceftriaxone and a single 1 g oral dose of azithromycin for the treatment ofuncomplicated…
This study is conducted to discover if bacterial vaginosis is related to the pregnancy rate in couples undergoing assisted reproduction.
The present study aims to assess the feasibility of deuterated water dosing in critically ill patients to assess long-term in vivo skeletal muscle protein synthesis rates.
We aim to determine the impact and seriousness of other TBDs in the Netherlands by measuring the prevalence and describing the clinical picture and the course of different other TBDs.
To assess clinical improvement of skin severity in patients with ichthyosis