336 results
To investigate if dried blood spot sampling of vancomycin and creatinine leads to less outpatient visits regarding vancomycin therapy compared to conventional sampling in OPAT service.
The objective of this study is to clinically validate a DBS method for vancomycin and creatinine, using a LC-MS/MS method.
This study has been transitioned to CTIS with ID 2024-515398-90-01 check the CTIS register for the current data. To determine whether 4 weeks of total antibiotic treatment duration is non-inferior to 6 weeks in patients with complicated SAB who have…
Determine the B-cell antibody response in patients with Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli bacteremia
Primary objective: - To establish a controlled human infection model in which healthy Dutch adult volunteers are inoculated with a wild-type Streptococcus pneumoniae bacterium with strict safety reviews.Secondary objectives: - To assess the…
To determine safety of the MediSieve Magnetic Hemofiltration System in healthy volunteers.
To determine the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership.
Objectives: 1) To compare the immune response of patients with or without sepsis presenting to the ED with a(n) (suspected) infection.2) To determine immune response aberrations that are associated with an increased risk of developing sepsis in…
To study the metabolic fate of amino acids derived from muscle protein breakdown in septic patients.
This study consists of two subsequent phases, with different objectives. The first phase includes a technical, explorative part with the objective of determining appropriate cut-off values and incubation times for the Sofia 2 Lyme+ WB FIA compared…
To determine the exposure of IV amoxicillin(-clavulanic acid) in pleural empyema fluid or complicated parapneumonic effusion and to assess the probability of PK/PD target attainment in the pleural fluid of patients diagnosed with pleural empyema or…
- To assess the effectiveness of rectal culture-guided antimicrobial prophylaxis for transrectal prostate biopsy (random ultrasound-guided, targeted MRI-guided or targeted MRI-ultrasound fusion guided) on infectious complications. - To compare the…
Primary objective:To establish whether saliva samples could be used as an alternative for blood samples in the therapeutic drug monitoring for gentamicin. To meet this objective, a PK model will be developed for gentamicin saliva concentrations.…
The aim of this study is to evaluate the effect of Gladskin treatment on the occurrence of skin symptoms in patients with NS. Secondary we want to retrieve information about the effect of Gladskin on quality of life, safety, the load of S. aureus…
To validate our previous findings, and to continue and deepen our exploration of biomarkers in BALF, providing endpoints that correlate with disease progression. We will do this through in-depth cellular and molecular profiling of BALF and blood,…
To develop a population pharmacokinetic model of teicoplanin in Intensive Care and Haematology patients for the purpose of dose individualization using therapeutic drug monitoring.
The main objective is to determine in what optimal dose PTX should be used in preterm infants suffering from sepsis. Previous clinical studies have already indicated the safety of the drug in preterm infants.
To investigate the safety and tolerability of controlled human urine transfusion in female patients with recurrent UTI*s.
Investigation of the impact of a treatment consisting of inhalation antibiotics and prolonged oral antibiotic course during a bacterial exacerbation on the prevention of further exacerbations.
To investigate whether the PK-PD target of ceftazidime (50%T>MIC) is attained in the first 24 hours of treatment in adult patients on general wards with adequate and impaired renal function receiving regular and reduced doses of ceftazidime.