336 results
The aim of this study is to establish the accuracy of Molecular Culture for prediciting the outcome of the traditional blood culture.
The REPLACE study aims to determine whether not changing the catheter (catheter retained) for catheter-associated urinary tract infections (CAUTI)affects the recurrence-risk of CAUTI.
The aim of this study is to evaluate and describe the PK of fosfomycin in individuals receiving oral treatment with multiple dosages of fosfomycin for recurrent and/or complicatedurinary tract infection. The results of this study will be used to…
Primary objectives:- To identify whether EBC can be used as a non-invasive method to measure the PK of salbutamol and tobramycin.- To determine whether the relationship in mild-moderate asthmatics between pulmonary lung function parameters and…
The primary objective is to establish the non-inferiority of treating a symptomatic urinary tract infection in patients with a long-term indwelling catheter for 5 days, as compared to the standard duration of 10 days of therapy. Secondary objectives…
To assess the impact of FMT on detectable intestinal carriage (by stool culture) of VRE in a 12 month follow-up period.
The aim of this study is to identify patient related, pathogen related, and contextual factors involved in S. aureus infections, especially S. aureus SSI, in the current surgical patient population in Europe, to identify patient groups with an…
Primary ObjectiveThe primary objective of the current project is to study the association between biomarkers for renal mitochondrial damage in sepsis with the change in renal function and mortality after sepsis.Secondary Objective(s)The secondary…
to safely reduce antibiotic prescription by a clinical decision rule in febrile children suspected of CAP
To determine the effects of fever control with external cooling during LPS-induced endotoxemia on:1. host immune response2. coagulation processes 3. tissue perfusion and oxygenation4. neurovascular coupling
Primary objective: To assess microbiological, immunological, genetic, clinical, cognitive-behavioral, and epidemiological determinants for development of persisting symptoms in both adult and juvenile Lyme patients, and establish prediction rules *…
The objective of the study is to develop a whole blood cell-mediated immunity test for Borrelia infection and investigate whether such a test can detect Borrelia infections more reliably than the currently used antibody tests in the early stage of…
The primary aim of our *Imaging of Fracture-related Infections trial (IFI trial)* is to assess the diagnostic accuracy of all commonly requested medical imaging techniques (WBC scintigraphy, FDG-PET/CT and MRI). The secondary aim is to establish…
To clarify the pathophysiological genetic pathway of the association between C. burnetii and NHL
2.1 HypothesisPrimary infection with Mtb induces temporal changes in the innate immune system, known trained innate (aangeboren) immunity, and the extent of trained innate immunity influences subsequent activation of adaptive (verworven) immunity.2.…
We aim to validate cellular tests to determine their value in diagnosing LB, as well as to describe the potential added value of these tests in the setting of a specialized Lyme center.
To determine the microbiological and clinical cure rate after 14 days.
The primary goal is to evaluate the presence and type of skin disorders in patients with a PID. Secondary objectives are to determine the presence of S. aureus on the lesional skin and/or nose in patients with a PID and to evaluate the presence of…
To determine the efficacy of a filter-based depletion of RBC-pathogen complexes by a single apheresis tretatment in patients with sepsis.
Primary Objective: To develop a pharmacokinetic model of clindamycin in patients of different BMI categories to determine the relevant obesity related covariates. Secondary Objective(s):To determine the variability and influence of clindamycin…