336 results
Primary objective: - To characterize hematopoietic progenitor cells in human bone marrow before and after endotoxemia (by evaluating hematopoietic lineage differentiation and functional capacity). Secondary Objectives: - To determine the effects of…
2.1 Primary objective(s)The primary objective of this study is to determine whether a CRP guided and PCT guided treatment strategy (strategies mentioned below) can be used to safely and effectively reduce the duration of antibiotic treatment as…
The aim of this study is to analyze the long-term effect of full-mouth tooth extraction and subsequent implant placement on the oral microflora (colonization of implants), using 16S next-generation sequencing technique. A secondary aim is to analyse…
(1) To determine the presence of T. pallidum DNA as proxy for the infectiousness of peripheral blood, urethral, anal and pharyngeal mucosa in infectious syphilis. (2) To evaluate T. pallidum polymerase chain reaction test (Tp-PCR) to diagnose…
The objective of this study is to determine the incidence of chronic Q fever and seronegativity in vascular patients that were seropositive after the Dutch Q fever outbreak. Seropositivity can indicate a past resolved Q fever infection or chronic Q…
Primary objective: To study the pharmacokinetics of gentamicin, tobramycin, vancomycin and ciprofloxacin in morbidly obese patients and compare with normal weight patients. Secondary objectives: To assess the influence of covariates (such as TBW,…
To validate and demonstrate reproducibility of the identified sepsis CR gene signature in participants from different age groups. The validation multicenter study will also lead to biomarker refinement of the original core set of 31 genes tailored…
This study focuses on the evaluation of Bonalive in bone defect healing and osteomyelitis treatment and it aims to investigate the bone healing capacity of BonAlive bioactive glass in patients who underwent debridement surgery in osteomyelitis…
The purpose of this pilot study is to determine the optimal timing to replace a catheter in patients with an indwelling catheter and systematic symptoms of an UTI.
Primary; to determine vaccine- and non-vaccine serotype-specific pneumococcal carriage by culture. Secondary; to determine pneumococcal presence, density and multi-serotype carriage analysis using molecular methods, impact of PCV on presence of…
Primary objective of the study is to determine whether prolonged use of 96 hours leads to growth of microorganisms (type and numbers (CFU/ml)) in enteral tube feeding sets. Secondary objectives are the occurrence of gastrointestinal events/ new…
This pilot study aims to assess the feasibility, safety and preliminary efficacy of a novel thermosensitive hyaluronic acid gel with an octenidine preservative system as an adjunct to standard non-surgical periodontal treatment. The use of a blinded…
Primary objective: To establish a controlled human infection model for C. difficile which is safe, well tolerated and results in microbiological and clinical endpoint in ideally >=70% of volunteers. Secondary objectives:- Assess colonisation…
A pilot study on digital coaching in rUTI at the Urology Department of Isala tested an app-based treatment additional to standard care.[8] The app provides information on rUTI aetiology, lifestyle recommendations, treatments, and the value of…
To determine prevalence rates of H. pylori infection within gastroenterologists, gastroenterologists and endoscopy nurses (in training).
The aim of this study is to investigate whether the transfer of antibodies from mother to infant is less effective in infants with intrauterine growth restriction (FGR) compared to term-born infants without intrauterine growth restriction or who are…