336 results
Clinical validation of a dried blood spot (DBS) method for the analysis of rifampicin (RIBOD study).
PrimairyTo clinically validate a finger prick DBS method compared to conventional venous sampling for the analysis of rifampicin.Secondairy* Feasibility of the novel finger prick DBS method in the target population will be assessed. This includes…
Primary• To determine changes over time, since introduction of PCV vaccination in National Immunization Program, in nasopharyngeal colonization frequencies of total vaccine- and non-vaccine serotypes of S. pneumoniae in healthy 24-month-old and 46-…
the first objective of this study is to quantify the impact of chronic Q-fever or QFS on work status and psychosocial functioning. Secondly, we will identify factors that are associated with these limitations, to determine which subgroups of…
Whooping cough is very contagious. Earlier research shows that family members of a child with whooping cough are often also infected with the pertussis bacterium. However, not everyone who is infected with the bacterium develops symptoms. In this…
The quality and quantity of the innate immune response to bacteria should be tightly regulated leading to resolution of infection while minimizing damage to host tissue. We hypothesize that this regulation depends on gestational age at delivery and…
Aim of the study:To investigate the role of the CD200/CD200R axis on the responsiveness of whole blood, peripheral blood mononuclear cells (PBMCs) and neutrophils to a proinflammatory challenge in the immunoparalysed state in sepsis patients.…
The main purpose of this study is to assess the long-term antibody responses and cellular memory immunity against B. pertussis in a cohort of Dutch children, 8-9 years of age, who have been vaccinated with aP in the first year of life. Furthermore,…
Primary objective: To determine the added diagnostic value of the lytA qPCR on samples of the upper respiratory tract on top of routine microbiological tests in detecting pneumococci as responsible pathogen in patients with CAP.Secondary objective (…
Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.
Investigate the effects of aP booster vaccination in children, young adults and elderly on the (long-term) immune response to B. pertussis in three European countries with a different epidemiological background and primary vaccination schedule for…
Prospectively investigate whether ciprofloxacin, administered as antibiotic prophylaxis in patients treated for haematological malignancies (with or without gastro-intestinal mucositis), in the currently recommended dosing regimen (500 mg orally or…
This pilot study is designed to evaluate the feasibility of field activities and if necessary adjust the methods for the full-scale study. Primary Objective: to evaluate the recruitment, retention and compliance rates for a prospective cohort study…
Identification of T cell epitopes that will serve as the basis for a novel Q fever vaccine with fewer side effects. This will be done by determining ex vivo the effect of Cb-derived T cell epitopes on IFN-γ production in blood of healthy volunteers…
To assess if short antibiotic treatment (3x24 hours) with an anti-pseudomonal carbapenem (imipenem-cilastatin or meropenem) is safe (NON-INFERIOR) with regard to treatment failure in comparison with extended treatment (at least 9x24hours) of high-…
The primary aim of the study of to investigate time and concentration of cefazolin above the MIC. The main secondary aim is to investigate influence of cardiac surgery and use of CPB on PK parameters of cefazolin. We aim investigate the new dosing…
To identify nasal microbial communities associated with Staphylococcus aureus carriage and study the influence over time of S. aureus-targeted decolonization treatment on these microbial communities
I.To assess the utility of point-of-care measurements of blood CRP and PCT levels to support clinical rules for diagnosing urinary tract infections UTI in nursing home residents.II. To develop and assess strategies that facilitate implementation of…
*Premature infants and maternal pertussis immunization. Is second trimester vaccination beneficial?*
Our primary objective is to evaluate non-inferiority of anti-Pertussis Toxin (PT) IgG in term infants at 2m of age born of mothers having received a pertussis vaccine between 20-24w Gestational Age (GA) compared to a reference anti-PT IgG at 2m of…
The primary objectives of the NO GBS study part 1 are to: - determine the clinical characteristics and outcome, and the prevalence of risk factors used by Dutch guidelines for risk assessment in GBS and E. coli meningitis and sepsis cases aged 0-3…
Primary objectives of the study are: 1. Defining the optimal image acquisition time window after FDG injection for PET/CT imaging in patients suspected of endocarditis2. Assessing the impact of gating (respiratory and ECG) on PET/CT image quality in…