57 results
The primary objective is to compare antibody responses against the pneumococcal vaccine strains and Influenza virus vaccine types in blood and saliva of older individuals with respect to frailty, taking sex differences into account. The overall aim…
This study has been transitioned to CTIS with ID 2024-513640-29-00 check the CTIS register for the current data. The aim of this study is to investigate the immune response to a primary and a booster immunization with a tetravalent MenACWY-TT…
This study has been transitioned to CTIS with ID 2024-515398-90-01 check the CTIS register for the current data. To determine whether 4 weeks of total antibiotic treatment duration is non-inferior to 6 weeks in patients with complicated SAB who have…
Our primary objective is to evaluate the effect of an enhanced perioperative care program added on to usual care on the incidence of SSI. Secondary objectives are to evaluate SSI rate at 3 months follow-up, assessment of health and disability with…
The primary objective of this study is to examine clinical and radiographical parameters when executing:- adjuvant antibiotic therapy versus no antibiotic therapy in the resective surgical treatment of 0-, 1- and 2-wall bone defects due to peri-…
Investigation of the impact of a treatment consisting of inhalation antibiotics and prolonged oral antibiotic course during a bacterial exacerbation on the prevention of further exacerbations.
This study has been transitioned to CTIS with ID 2024-513394-42-01 check the CTIS register for the current data. To assess long-term outcomes in low-immunological risk renal transplant patients beyond one year after transplantation using tacrolimus…
The main objective of this study is to determine differences in vaccine responses in the pre-elderly age group (50-65 years of age) to a primary immunization with vaccine antigens to which no or (very) low pre-vaccination antibody levels and memory…
Primary Objective: - To study the pharmacokinetics (CL, Vd, and F) of ciprofloxacin in cachectic elderly patients and compare with normal weight participants.Secondary Objective(s): - To assess the influence of covariates (such as TBW, LBW, serum…
The aim of this multicenter open-label, randomized controlled trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
The primary objective is to establish the non-inferiority of treating a symptomatic urinary tract infection in patients with a long-term indwelling catheter for 5 days, as compared to the standard duration of 10 days of therapy. Secondary objectives…
PRIMARY* To demonstrate the non-inferiority of intravenous-to-oral antibiotic switch therapy in clinically stable neonates with probable bacterial infection compared to a complete course of intravenous antibiotic therapySECONDARY* To describe the…
We plan to conduct a large, pragmatic, multicentre, randomised non-inferiority trial to determine whether the use of intraoperative dexamethasone, a widely used antiemetic in perioperative medicine, is associated with an unacceptable increased risk…
To determine the microbiological and clinical cure rate after 14 days.
Primary objective: To study the pharmacokinetics of gentamicin, tobramycin, vancomycin and ciprofloxacin in morbidly obese patients and compare with normal weight patients. Secondary objectives: To assess the influence of covariates (such as TBW,…
This study focuses on the evaluation of Bonalive in bone defect healing and osteomyelitis treatment and it aims to investigate the bone healing capacity of BonAlive bioactive glass in patients who underwent debridement surgery in osteomyelitis…
The aim of this study is to investigate whether the transfer of antibodies from mother to infant is less effective in infants with intrauterine growth restriction (FGR) compared to term-born infants without intrauterine growth restriction or who are…