159 results
The main objective of this study is to determine the number of therapeutic first trough levels (vancomycin serum concentrations between 10 and 15 mg/L), as well as subtherapeutic (serum concentrations < 10 mg/L) and supratherapeutic (serum…
The primary objective of this randomized controlled trial is to compare the clinical effect of decontamination of the implant surface during the surgical treatment of peri-implantitis using air polishing or hand instruments. The secondary objective…
Clinical validation of a dried blood spot (DBS) method for the analysis of rifampicin (RIBOD study).
PrimairyTo clinically validate a finger prick DBS method compared to conventional venous sampling for the analysis of rifampicin.Secondairy* Feasibility of the novel finger prick DBS method in the target population will be assessed. This includes…
Primary Objective: To investigate the additional effect of systemic antibiotics (amoxicillin 375 mg and metronidazole 250 mg) for non-surgical treatment of peri-implantitis in comparison to non-surgical treatment of peri-implantitis without the…
Our primary objective is to investigate whether noradrenaline exerts immunomodulatory effects in humans in vivo during experimental human endotoxemia. This will be determined by comparing plasma levels of various pro- and anti-inflammatory cytokines…
The primary objective of this pilot trial is to evaluate if adding mitoPO2 monitoring to standard anaesthetic management enables tissue oxygenation optimisation.
In this study we will investigate how safe the new compound VNRX-7145 and the combination of 2 study compounds, the new compound VNRX7145 and the approved compound ceftibuten, are and how well they are tolerated when they are used by healthy…
The aim of ImmunoSep is to study if personalized immunotherapy targeting either fulminant hyper-inflammation or immunoparalysis is able to improve sepsis outcomes.
To assess if short antibiotic treatment (3x24 hours) with an anti-pseudomonal carbapenem (imipenem-cilastatin or meropenem) is safe (NON-INFERIOR) with regard to treatment failure in comparison with extended treatment (at least 9x24hours) of high-…
The primary aim of the study of to investigate time and concentration of cefazolin above the MIC. The main secondary aim is to investigate influence of cardiac surgery and use of CPB on PK parameters of cefazolin. We aim investigate the new dosing…
The primary objectives of the trial are to investigate the effect of the use of inhaled colistimethate sodium, administered twice daily via the I-Neb for 12 months, compared to placebo in subjects with non*cystic fibrosis bronchiectasis (NCFB)…
This study has been transitioned to CTIS with ID 2023-505483-11-00 check the CTIS register for the current data. To investigate if early transition to oral treatment after two weeks or longer of IV antibiotic therapy is non-inferior to standard six…
Primary objective: To evaluate the safety and tolerability of single ascending i.v. doses of OMN6 in healthy young and elderly adult subjects.Secondary objective: To evaluate OMN6 PK in plasma following single ascending i.v. doses in healthy young…
The objective of the proposed study is to determine the effectiveness, safety and cost-effectiveness of a strategy of cefuroxime combined with short course treatment with aminoglycosides compared to a strategy of ceftriaxone monotherapy in patients…
A non-inferiority/superiority trial was designed for the treatment of uncomplicated cystitis in the Dutch community, in which we compare a 1-day and 3-day regimen of FT to a 5-day regimen of nitrofurantoin to investigate the effect on time to…
This study has been transitioned to CTIS with ID 2024-520379-28-00 check the CTIS register for the current data. To compare exposure to ciprofloxacin between patients with impaired renal function (eGFR < 30 ml/min/1.73m2) admitted to a…
This study has been transitioned to CTIS with ID 2023-506589-30-00 check the CTIS register for the current data. The purpose of this study is to demonstrate the efficacy of 9-valentextraintestinal pathogenic Escherichia coli vaccine (ExPEC9V)…
>Primary objective:During the intervention period (from randomisation until and including Term Equivalent Age [TEA]): To investigate the effect of the test product vs. the control product given to preterm infants born at 24+0 to <30+0…
To determine the efficacy of oral fosfomycin in comparison to the standard of care oral ciprofloxacin, in the treatment of FUTI after initial empirical treatment with intravenous antibiotics.To describe the pharmokinetic profile of men treated with…
To investigate the influence of flucloxacillin treatment on CYP - and UGT substrate plasma concentration, to gain further understanding of potential clinically relevant drug-drug interactions with flucloxacillin.