159 results
This study has been transitioned to CTIS with ID 2024-515398-90-01 check the CTIS register for the current data. To determine whether 4 weeks of total antibiotic treatment duration is non-inferior to 6 weeks in patients with complicated SAB who have…
To determine safety of the MediSieve Magnetic Hemofiltration System in healthy volunteers.
To determine the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership.
To determine the exposure of IV amoxicillin(-clavulanic acid) in pleural empyema fluid or complicated parapneumonic effusion and to assess the probability of PK/PD target attainment in the pleural fluid of patients diagnosed with pleural empyema or…
To investigate whether minimally processed milk product can decrease the diarrheagenic E. coli-induced changes in reported stool frequency and gastrointestinal complaints.
The aim of this study is to evaluate the effect of Gladskin treatment on the occurrence of skin symptoms in patients with NS. Secondary we want to retrieve information about the effect of Gladskin on quality of life, safety, the load of S. aureus…
Primary objective:• To evaluate the safety and tolerability of single intravenous (i.v.) doses of XAB05 in healthy subjects.Secondary objective:• To characterize the plasma pharmacokinetic (PK) profile of single i.v. doses of XAB05 in healthy…
To evaluate the safety and efficacy of a 14-day course vs a 28 day course of AZLI 75 mg three times a day (TID) in subjects with new onset PA respiratory tract colonization/infection as determined by PA eradication over a 28-day post treatment…
The purpose of this study is to investigate how safe ceftibuten is and how well it is tolerated when it is administered at higher dose levels than those currently available on the market (daily doses up to 400 mg). It will also be investigated how…
Primary objectivesTo determine the bacterial eradication capacity of ertapenem, fosfomycine and gentamicine compared to the reference treatment (ceftriaxone) in uncomplicated anogenital gonococcal infections (at one included infection site) by…
To develop a population pharmacokinetic model of teicoplanin in Intensive Care and Haematology patients for the purpose of dose individualization using therapeutic drug monitoring.
The main objective is to determine in what optimal dose PTX should be used in preterm infants suffering from sepsis. Previous clinical studies have already indicated the safety of the drug in preterm infants.
Investigation of the impact of a treatment consisting of inhalation antibiotics and prolonged oral antibiotic course during a bacterial exacerbation on the prevention of further exacerbations.
To investigate whether the PK-PD target of ceftazidime (50%T>MIC) is attained in the first 24 hours of treatment in adult patients on general wards with adequate and impaired renal function receiving regular and reduced doses of ceftazidime.
The main objectives are to investigate the pharmacokinetic properties of DP tobramycin via the Cyclops® at different dosages in children with CF, together with the local tolerability.
This study has been transitioned to CTIS with ID 2024-513394-42-01 check the CTIS register for the current data. To assess long-term outcomes in low-immunological risk renal transplant patients beyond one year after transplantation using tacrolimus…
Primary Objective: - To study the pharmacokinetics (CL, Vd, and F) of ciprofloxacin in cachectic elderly patients and compare with normal weight participants.Secondary Objective(s): - To assess the influence of covariates (such as TBW, LBW, serum…
To explore the effects of HBOT on immunologic parameters and oxidative stress.
The primary objective is to determine the absorption of orally administered antibiotics in patients with SBS, to guide in clinical decision making when faced with catheter related infections.
The purpose of this study is to investigate how quickly and to what extent a new tablet formulation of CG-549 is absorbed and eliminated from the body. This information will be used to select a dose of CG-549 which is expected to be safe and…