159 results
The aim of this study is to evaluate and describe the PK of fosfomycin in individuals receiving oral treatment with multiple dosages of fosfomycin for recurrent and/or complicatedurinary tract infection. The results of this study will be used to…
Primary objectives:- To identify whether EBC can be used as a non-invasive method to measure the PK of salbutamol and tobramycin.- To determine whether the relationship in mild-moderate asthmatics between pulmonary lung function parameters and…
The primary objective is to establish the non-inferiority of treating a symptomatic urinary tract infection in patients with a long-term indwelling catheter for 5 days, as compared to the standard duration of 10 days of therapy. Secondary objectives…
To assess the impact of FMT on detectable intestinal carriage (by stool culture) of VRE in a 12 month follow-up period.
To demonstrate non-inferiority of oral fosfomycin-trometamol compared to oral ciprofloxacin as a step-down treatment for E.coli AF-UTI in women for the cumulative incidence of survival and clinical cure (resolution of symptoms) 6-10 days post-…
To determine the effects of fever control with external cooling during LPS-induced endotoxemia on:1. host immune response2. coagulation processes 3. tissue perfusion and oxygenation4. neurovascular coupling
We plan to conduct a large, pragmatic, multicentre, randomised non-inferiority trial to determine whether the use of intraoperative dexamethasone, a widely used antiemetic in perioperative medicine, is associated with an unacceptable increased risk…
To determine the microbiological and clinical cure rate after 14 days.
The aim of this study is to investigate efficacy of a manuka honey lavage in the treatment of three distinct disorders; persistent clostridium difficile infection (CD), budesonide dependent microscopic colitis (MC), and therapy refractory irritable…
To determine the efficacy of a filter-based depletion of RBC-pathogen complexes by a single apheresis tretatment in patients with sepsis.
Primary Objective: To develop a pharmacokinetic model of clindamycin in patients of different BMI categories to determine the relevant obesity related covariates. Secondary Objective(s):To determine the variability and influence of clindamycin…
2.1 Primary objective(s)The primary objective of this study is to determine whether a CRP guided and PCT guided treatment strategy (strategies mentioned below) can be used to safely and effectively reduce the duration of antibiotic treatment as…
The goal of this study is to evaluate the effect of Gladskin on usage of topical corticosteroids in patients with atopic dermatitis. Secondary goals are to retrieve information about the effect of Gladskin on clinical symptoms, quality of life,…
Primary objective: To study the pharmacokinetics of gentamicin, tobramycin, vancomycin and ciprofloxacin in morbidly obese patients and compare with normal weight patients. Secondary objectives: To assess the influence of covariates (such as TBW,…
This study focuses on the evaluation of Bonalive in bone defect healing and osteomyelitis treatment and it aims to investigate the bone healing capacity of BonAlive bioactive glass in patients who underwent debridement surgery in osteomyelitis…
To evaluate the inflammatory reducing effect, in the periodontal tissues and systemically, of vitamin C with quercetin and other flavonoids in untreated periodontal disease. Secondly to evaluate the effect of vitamin C with quercetin and other…
Compare PRF and EMD regenerative potential in the surgical treatment of molar teeth with periodontal destruction in the furcation area.Evaluate induced Healing potential of the two materials. Correlate healing pattern with biomarkers in blood and…
The purpose of this pilot study is to determine the optimal timing to replace a catheter in patients with an indwelling catheter and systematic symptoms of an UTI.
This pilot study aims to assess the feasibility, safety and preliminary efficacy of a novel thermosensitive hyaluronic acid gel with an octenidine preservative system as an adjunct to standard non-surgical periodontal treatment. The use of a blinded…