83 results
To identify complement donors with no or low antibodies to Meningococcal strains to be used used as a complement source in SBAs against a panel of meningococci during evaluation of clinical trial samples
We want to determine whether Lacprodan® PL-20 can effectively protect against enterotoxigenic E.coli induced travellers* diarrhea in humans. In the present double-blind, placebo-controlled, randomized parallel study, the effect of oral milk protein…
We want to study whether consumption of Protecflor can improve the resistance of humans to intestinal ETEC infection. An important parameter of intestinal resistance is the so-called colonization resistance. The colonization resistance is inversely…
The aim of this study is to analyze the effect of full-mouth tooth extraction on the oral microflora, using both culturing and PCR techniques.
I. Evaluation of the nature and maintenance of specific cellular immune mechanisms after infection with Bordetella pertussis in different age groups, to identify critical parameters for pertussis re-emergenceII. To relate individual patient*s…
Primary objectiveThe primary objective of this trial is to compare TauroSept® (taurolidine 2% solution) with saline solution 0.9% as catheter lock solutions to prevent catheter-related bloodstream infections (CRBSI) in patients on home parenteral…
The aim of this study is to investigate the immune response to a tetravalent MenACWY-TT vaccine in 10-, 12- and 15-year old children primed with the monovalent MenC-TT conjugate vaccine at a young age and to1. determine whether the MenC-specific…
Objective: The main objective is to demonstrate superiority of the intravesical overnight instillation of gentamicin versus oral antibiotic prophylaxis in reducing the number of recurrences of UTI and extending the time-interval to a next UTI, in…
Primary objective is to investigate if donor feces infusion is effective in eradication of ESBL producing Enterobacteriaceae in the large intestine. Secondary objective is to determine whether ESBL decolonisation of the large intestine actually…
To compare splenic function between patients who received splenectomy and patients treated with embolisation. Furthermore, splenic function between patients with different types of embolisation (proximal versus distal) will be compared
We want to investigate the hypothesis that daily use of the above mentioned supplements (consisted of concentrated fruit en vegetables) results in improved healing of periodontal tissues in patients suffering from periodontitis. Besides we…
1) To test the feasibility of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in newborn babies.2) To test the safety of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in…
Objective: to study host and pathogen determinants of S. aureus infection to identify a putative antigen as target for the development of a prophylactic vaccine against S. aureus.
Investigate the effect of acidic and neutral oligosaccharides supplemented enteral nutrition on infectious morbidity, feeding tolerance and short-term outcome in VLBW infants. Furthermore, an attempt is made to elucidate the role of acidic and…
To decrease the incidence of sepsis after removal of central venous catheters in the neonatal intensive care unit.
Objective: 1) to assess whether adequate serum and interstitial fluid levels of cefazolin are reached during surgery in obese and non-obese patients, 2) to develop a population pharmacokinetic model for cefazolin which allows the characterization of…
To study the immune response to vaccination with influenza virus vaccine, conjugated Hib and pneumococcal vaccine after treatment with rituximab in association with the reconstitution of immune function (in terms of amount of B-cells and…
To determine the effect of probiotics (microbial food supplements) on acquisition rates and colonization prevalence of CC17 ARE in two wards where ARE-colonization is endemic.
The primary objective of the study is to determine the effect of atazanavir-induced hyperbilirubinemia on systemic activation of the innate immune response induced by human endotoxemia.Secondary objectives are:- To determine if the vascular…
We want to study whether consumption of Lactobacillus acidophilus NCFM* can improve the resistance of humans to intestinal ETEC infection. An important parameter of intestinal resistance is the so-called colonization resistance. The colonization…