83 results
This prospective randomised study has the primary objective to prove a reduction of postoperative wound infections after direct preoperative use of a microbial sealant in the form of Integuseal for vascular procedures on lower extremities. We aim at…
To investigate whether application of APLG will lead to reduction in: 1) sternal wound infections 2) vessel harvest site infections 3) postoperative blood loss 4) postoperative pain
Primary:To determine trends in vaccine- and nonvaccine-serotype S. pneumoniae asymptomatic colonisation in healthy 11-month-old and 24-month-old infants who have been immunized according to the Dutch NIP with 7-valent pneumococcal conjugate vaccine…
Do pre-processed bone chips have lower contamination rates compared to femoral heads, morselised at the operating theatre measured at different moments during hip revision arthroplasty?
In this study we want to study:1) what is the prevalence of CA-MRSA asymptomatic carriership among MSM policlinic visitors?2) What are risk factors for CA-MRSA carriership and/or infections among MSM?3) Is CA-MRSA among MSM transmitted through…
To assess the effects and costs of cranberry use to prevent symptomatic UTIs in nursing home residents.
How long does B-cell memory persist after a single conjugate MenC vaccination and which cells are involved? How is this related to the age of first vaccination? And how to define correlates of protection for immunity and memory after MenC conjugate…
We aim to study the efficacy of honey to prevent skin colonization with microflora at central venous catheter insertion sites.
Determine asymptomatic nasopharyngeal pneumococcal carriage and serotype distribution in elderly aged 65-70 years, 71-80 years ald 80 years and older. Assessment of the value of PCR compared with conventional culture methods.
The purpose of this study is to determine whether it is useful to decolonize patients undergoing primary hip or knee replacement surgery from the S. aureus skin bacteria.
Primary Objective: In the CORAL study we want to determine whether increasing the inoculation dose of diarrhoeagenic E. coli to 5*10^10 CFU and addition of a second challenge 1*10^10 CFU will result in an increased effect-size and duration of…
The aim of this study is to analyze the long-term effect of full-mouth tooth extraction on the oral microflora, using the 16S next-generation sequencing technique.
Whooping cough is very contagious. Earlier research shows that family members of a child with whooping cough are often also infected with the pertussis bacterium. However, not everyone who is infected with the bacterium develops symptoms. In this…
To study the effect of sweetener oral rinses on the oral microbiome composition.
The main purpose of this study is to assess the long-term antibody responses and cellular memory immunity against B. pertussis in a cohort of Dutch children, 8-9 years of age, who have been vaccinated with aP in the first year of life. Furthermore,…
Prospectively investigate whether ciprofloxacin, administered as antibiotic prophylaxis in patients treated for haematological malignancies (with or without gastro-intestinal mucositis), in the currently recommended dosing regimen (500 mg orally or…
This pilot study is designed to evaluate the feasibility of field activities and if necessary adjust the methods for the full-scale study. Primary Objective: to evaluate the recruitment, retention and compliance rates for a prospective cohort study…
This study aims to evaluate the changes in microbial composition of the oral microbiome (main objective), changes in proportion of the red fluorescing plaque (RFP) and in gingival bleeding on marginal probing (BOMP) (secondary objectives) after…
The objective is to evaluate if topical benzoyl peroxide reduces the presence of C. acnes on the skin of the shoulder compared to a topical placebo?
To investigate the effect of a cows-milk-based formula supplemented with synbiotics from t=0 to t=21, t=42 and t=84 days after amoxicillin or amoxicillin/clavulanic acid treatment in toddlers aged 1, 2 and 3 years old on: - change in proportion of…