83 results
Primary:- To evaluate the effect of suvratoxumab on reducing the incidence of nosocomial all-cause pneumonia.Secondary:- To evaluate the safety of a single IV dose of suvratoxumab.- To evaluate the effect of suvratoxumab on reducing the incidence of…
The main purpose of this study is to investigate the longitudinal effects of an aP booster vaccination in adults, on long-term humoral and cellular memory immunity against B. pertussis. By measuring antibody levels against the various pertussis…
Primary objectiveTo assess whether prevention of aspiration, infections, and fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly…
To investigate the effects of taurolidine on human blood cells by identification of gene expression, protein production and immune response.
The sites of the Netherlands will only participate in cohort 2. Primary objectives - cohort 2: - To evaluate the safety and reactogenicity of the selected dose of ExPEC10V in participants >=60 years of age with a history of UTI in the past 5…
This study has been transitioned to CTIS with ID 2023-509105-72-00 check the CTIS register for the current data. * To demonstrate the efficacy of VLA15 in preventing confirmed Lyme disease in the Lyme disease season after completion of the primary…
Primary Objective: Primary objective of this trial will be to determine whether iNPWT reduces the number of patients with clinically relevant* SSOs after (potentially) contaminated ventral hernia repair <30 days after surgery. *A SSO is…
The main objective is to investigate the effect of oral tributyrin on plasma endotoxin in patients with acute pancreatitis.
Primary Objective: To assess the efficacy and safety of faecal microbiota transfusion in female renal transplant recipients with intestinal carriage of extended-spectrum β-lactamase Enterobacteriaceae (ESBL-E) and/or carbapenemase producing…
Primary objective: The primary objective of this study is to investigate if taking methenamine hippurate reduce the need for antibiotic usage due to recurrent UTI (measured as the number of courses of antibiotics).Secondary objectives:to investigate…
Primary objective: - To establish a controlled human infection model in which healthy Dutch adult volunteers are inoculated with a wild-type Streptococcus pneumoniae bacterium with strict safety reviews.Secondary objectives: - To assess the…
Our primary objective is to evaluate the effect of an enhanced perioperative care program added on to usual care on the incidence of SSI. Secondary objectives are to evaluate SSI rate at 3 months follow-up, assessment of health and disability with…
To investigate the safety and tolerability of controlled human urine transfusion in female patients with recurrent UTI*s.
The main objective of this study is to determine differences in vaccine responses in the pre-elderly age group (50-65 years of age) to a primary immunization with vaccine antigens to which no or (very) low pre-vaccination antibody levels and memory…
Primary objective: 1. To prove the concept that 90-day treatment with probiotics can restore microbiome composition and diversity in patients treated for community-acquired pneumonia. Secondary objective: 1. Investigate possible differences in…
The aim of this multicenter open-label, randomized controlled trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
The aim of this study is to investigate the long-term immune response and determine the persistence of functional antibodies to the tetravalent MenACWY-TT vaccine administered as a second meningococcal vaccination after 5 years. This study will…
Determine the efficacy of medical grade honey to reduce or prevent bacterial colonization at skin of intensice care patients.
To determine the effect of Pre-OP, in addition to perioperative intravenous antimicrobial prophylaxis on the cumulative incidence of deep surgical site infections (SSI) and/or mortality within 30 days after surgery in patients undergoing elective…
The objective of this study is to determine whether long term (5 days) postoperative (cefazolin) antibiotics will decrease the rate of infection following lower extremity tumor surgery, when compared to short term (24 hours) postoperative (cefazolin…