78 results
The present study aims to assess the feasibility of deuterated water dosing in critically ill patients to assess long-term in vivo skeletal muscle protein synthesis rates.
The primary objective is to explore the urine microbiome (urobiome) composition of postmenopausal women with and without RUTI at five scheduled time points during one year of follow-up, as well as before, during, and after UTI episodes when they…
The main objective of the MeninGene study is to identify genetic risk factors in host and pathogen influencing susceptibility to bacterial meningitis, and the rate of complications, unfavourable outcome and death.
Objectives: 1) To compare the immune response of patients with or without sepsis presenting to the ED with a(n) (suspected) infection.2) To determine immune response aberrations that are associated with an increased risk of developing sepsis in…
To study the metabolic fate of amino acids derived from muscle protein breakdown in septic patients.
To validate our previous findings, and to continue and deepen our exploration of biomarkers in BALF, providing endpoints that correlate with disease progression. We will do this through in-depth cellular and molecular profiling of BALF and blood,…
The primary objective of this study is to examine clinical and radiographical parameters when executing:- adjuvant antibiotic therapy versus no antibiotic therapy in the resective surgical treatment of 0-, 1- and 2-wall bone defects due to peri-…
Primary Objectives: 1.To obtain insight in the role of altered DNA methylation in blood leukocytes (monocytes and neutrophils) in innate immune responses and host defense in patients with CAP.2.To determine the composition and function of the gut…
Study Objective(s): To determine if HA dermal filler late occurring (> 4 weeks and < 2 years) nodules are associated with bacterial contamination (independent of filler type) and to characterize the histological response.
Primary objectives:1. To study the development of the infant microbiome, defined as the microbial communities in the nasopharynx (transnasal), oral cavity (saliva), skin and gastro-intestinal tract (faeces), in healthy infants born by vaginal…
Western Management strategies have been ineffective to modify the poor prognosis of GC. This proposal will focus on this specific challenge to *improve GC outcomes*, and will seek to gather evidence through international high-quality translational…
This study aims to provide insights into the processes and key host immune and microbiota factors that determine the infection kinetics, transmission and development of immunity during such infections. Furthermore, this study will enable us to…
Primary ObjectiveThe primary objective of the current project is to study the association between biomarkers for renal mitochondrial damage in sepsis with the change in renal function and mortality after sepsis.Secondary Objective(s)The secondary…
To clarify the pathophysiological genetic pathway of the association between C. burnetii and NHL
Primary objective: - To characterize hematopoietic progenitor cells in human bone marrow before and after endotoxemia (by evaluating hematopoietic lineage differentiation and functional capacity). Secondary Objectives: - To determine the effects of…
Primary objective: To establish a controlled human infection model for C. difficile which is safe, well tolerated and results in microbiological and clinical endpoint in ideally >=70% of volunteers. Secondary objectives:- Assess colonisation…
To determine prevalence rates of H. pylori infection within gastroenterologists, gastroenterologists and endoscopy nurses (in training).
To explore the clinical role of infection and inflammation in lumbar and cervical radiculopathy.