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PRognostic hEModynamIc profiling in the acUte ill eMergency department patient: PREMIUM registry

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Testing for sepsis in primary care: diagnostic and prognostic study investigating the potential benefits of point-of-care testing

The objective of the study is to improve the detection of sepsis in primary care by developing a clinical decision rule for GPs, consisting of the most relevant clinical features and point-of-care (POC) measurements of biomarkers. This decision rule…

Hemodynamic Phenotype-Based, Capillary Refill Time-Targeted Resuscitation In Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial (A2)

To test if a CRT-targeted resuscitation based on clinical hemodynamic phenotyping can improve a hierarchical clinical outcome - mortality, time to cessation of vital organ support, and length of hospital stay, all within 28 days - in septic shock…

Detection of neonatal sepsis with non-invasive transcutaneous blood gas monitoring

The primary objective of this study is to determine the relation of delta PO2 (PaO2-tcPO2) and delta PCO2 (tcPCO2-cPCO2) levels to sepsis. The secondary aims are to determine the factors that influence delta PO2 and delta PCO2 and to determine the…

Preterm Immune system development and response to Immunization

Primary objective is to study the antibody immune response to routine vaccinations in very preterm infants (GA<32 weeks). Secondary aim is to study the immune system more extensively using flow cytometry, ELISA and single cell transcriptomics…

Procalcitonin-guided treatment regarding antibiotic use for acute COPD exacerbations: a prospective randomised controlled trial

Our main aim is to develop a biomarker-based method to decide whether treatment with antibiotics is required for treatment of individual hospitalized AECOPD patients. We hypothesize that our biomarker-based intervention, using PCT levels to guide…

Fluid management and individualized resuscitation in sepsis

The primary objective of this study is to evaluate the personalized hemodynamic resuscitation protocol, guided by the Baxter Starling, for sepsis patients within the first six hours after admission to the emergency department, in comparison to the…

BCG-induced epigenetic modifications in the NEXT generation

To study the possible epigenetic modifications in sperm cells after BCG vaccination

Vaccinations in the Immunocompromised population: paramount and paradox.

The objective of this study is to determine the immune response after hepatitis A and pneumococcal vaccination in different groups of ICPs. The overarching aim of the study is to improve vaccine regimens and to optimize guideline recommendations…

Technical validation of transport and temperature stability at room temperature of presepsin measured with Elecsys® Presepsin.

The objective of this pilot study is to assess whether transportation of the sample via a pneumatic tube system (PTS) has any detrimental effects on the recovery of presepsin levels, when compared to traditional hand-delivery. This research will be…