12 results
The general objective of HELIUS is to describe (trends in) patterns of chronic conditions across six ethnic groups over time, and to unravel the causes of (the unequal burden) of chronic diseases across ethnic groups, with an emphasis on…
The objective of the study is to improve the detection of sepsis in primary care by developing a clinical decision rule for GPs, consisting of the most relevant clinical features and point-of-care (POC) measurements of biomarkers. This decision rule…
To test if a CRT-targeted resuscitation based on clinical hemodynamic phenotyping can improve a hierarchical clinical outcome - mortality, time to cessation of vital organ support, and length of hospital stay, all within 28 days - in septic shock…
To study the long-term changes in DNA methylation and gene expression in sepsis survivors and their association with long-term morbidity and mortality after sepsis.
The primary objective of this study is to determine the relation of delta PO2 (PaO2-tcPO2) and delta PCO2 (tcPCO2-cPCO2) levels to sepsis. The secondary aims are to determine the factors that influence delta PO2 and delta PCO2 and to determine the…
Primary Objective: To compare nasal CD8+ T cell frequency between young adults and frail older adults.Secondary Objective(s): 1. In depth profiling of T cells in nose and blood of young adults and older adults with and without frailty.2. Assess the…
Our main aim is to develop a biomarker-based method to decide whether treatment with antibiotics is required for treatment of individual hospitalized AECOPD patients. We hypothesize that our biomarker-based intervention, using PCT levels to guide…
The primary objective of this study is to evaluate the personalized hemodynamic resuscitation protocol, guided by the Baxter Starling, for sepsis patients within the first six hours after admission to the emergency department, in comparison to the…
Primary objective: 1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…
The main objective is to investigate how mitochondrial function progresses over time in septic ICU patients. The secondary objective of the study is (a) to investigate how mitochondrial dynamics progress over time and how this is associated with…
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
The objective of this pilot study is to assess whether transportation of the sample via a pneumatic tube system (PTS) has any detrimental effects on the recovery of presepsin levels, when compared to traditional hand-delivery. This research will be…