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The effects of metformin on immune function.

The primary objective of the study is to evaluate the effects of orally administered metformin on the immune and metabolic responses of stimulated peripheral blood mononuclear cells (PBMC*s) and macrophages from healthy individuals.

An open phase 1, dose-escalating, clinical trial on the safety of a new liposomal adjuvant system, CAF01, when given with the tuberculosis subunit vaccine Ag85B-ESAT-6 as two injections with two months interval to healthy adult volunteers.

Primary:The primary objective is to evaluate the safety profile of an adjuvated Tb subunit vaccine (CAF01) administered in 50 µg Ag85B-Esat-6 alone, 50 µg Ag85B-Esat-6 alone with three escalating CAF01 dose levels, to four groups of healthy…

Genetic risk factors for hepatotoxicity during anti tuberculosis treatment.

1. The central hypothesis of this study is that genetic polymorphisms in drug metabolising enzymes and regulators of enzyme expression may predispose to ATDH. We propose to evaluate the presence of genetic polymorphisms among TB patients in…

A safety and immunogenicity phase 1 trial with an adjuvated TB subunit vaccine (Ag85B - ESAT-6 + IC31) administered in PPD positive volunteers at 0 and 2 months

Primary objective:The primary objective is to evaluate the safety of an adjuvated TB subunit vaccine administered in PPD positive volunteers at 0 and 2 months.Secondary objective:The secondary objective is to determine the immunogenicity profile of…

Nontuberculous mycobacterial cervicofacial lymphadenitis in children; diagnostic performance of the Capilia MAC antibody Elisa test and possible portals of entry

This study intends to investigate the diagnostic potential of the Capilia mac antibody Elisa test in children with a clinical suspicion of NTM cervicofacial lymphadenitis.Moreover, this study aims at investigating whether NTM possibly access the…

Immune responses to an in vivo challenge model using the tuberculin skin test in patients with mycobacterial infections

To determine the relationship between tissue immune responses and the clinical course of mycobacterial infections.

Non-Tuberculous Mycobacterial Skin and Soft Tissue Infections: Using a Site-of-Disease Approach to Understand Pathophysiology and Improve Outcome

To identify clinical and immunological parameters that predict the course of disease of non-tuberculous mycobacterial skin and soft tissue infections.