18 results
To examine the effect of BCG vaccination on the composition and function of the bone marrow.
Evaluation of therapeutic safety and clinical efficacy of MSC transplantation in septic shock.
The primary objective of the study is to determine the effects of hyperoxia and hypoxia in healthy volunteers on kinetics of HIF1α mRNA in circulating leukocytes. Secondary objectives are to determine the effects of hyperoxia and hypoxia on HIF1α…
To evaluate immune function and (the susceptibility for) oxidative damage under the influence of long-term olive-oil based TPN use in patients without an active underlying disease and compare this with findings in healthy controls
To determine whether tobramycin, administered in the gut, permeates from the gut into the blood and is subsequently excreted into the urine.
The objective of the study is to see whether donor feces infusions can help to eradicate ESBL in patients who carry ESBL.
To determine the effect of RIPC of the upper limb on the inflammatory response during human endotoxemia (infusion of LPS), as well as the additional effect of 7-day RIPC compared with single-dose RIPC.
Our hypothesis in patients admitted to the ICU because of septic shock is that fluid loading guided by transpulmonary thermodilution derived stroke volume variation (SVV) and extravascular lung water (EVLW) results in more ventilator free days (VFDs…
The primary objective of the present study is to determine the effects of the `strength ventilation` breathing technique and exposure to cold, both separately and in combination, on the inflammatory response during human endotoxemia. To this end, we…
The main objective of the proposed study is to investigate the effect of plasma products and albumin on markers of endothelial function in a human endotoxemia model.
The first objective is to explore the biological profile (e.g. the immunological profile, hypothalamic- pituitary-adrenal (HPA) axis, mitochondrial dysfunctioning, the gut microbiome) of adolescents with QFS and related fatigue disorders (CFS/ME,…
To determine the efficacy of a short high-dose treatment of oral prednisolone for persistent loss of smell after COVID-19 infection in the long term (>12 weeks). ADD: determining the clinical course/natural recovery of loss of smell and taste…
To investigate whether analgesic ear drops added to usual care (oral analgesics with/without antibiotics) provide superior ear pain relief over usual care in children presenting to primary care with ear pain and diagnosed with AOM .
To investigate whether timely delivery of CBT, i.e. 3 to 6 months after COVID-19 diagnosis or hospital discharge, will lead to a significant relevant reduction in fatigue severity (primary outcome), will lead to a clinically relevant reduction in…
The objective of the study is to determine the effect of BCG revaccination and high dose BCG vaccination on the induction and course of innate immune memory.
The primary objective is to determine whether the exposure to oral ciprofloxacin and amoxicillin is altered in hospitalized non-critically ill, febrile patients in need of IV antibiotics when they are acutely ill and febrile, compared to when they…
To investigate the effect of bisphosphonates and the MMR vaccine on BCG-induced trained immunity as a possible preventive approach against COVID-19
To assess the tolerance of RISA after its application in the root canal system during root canal treatment.