Search for a trial

Effect of C1-esterase inhibitor on systemic inflammation in trauma patients with a femur or pelvic fracture.

A previous study of from our laboratory showed that administration of the drug C1-INH (100E/kg) significantly reduced the concentration of circulating pro-inflammatory cytokines, such as IL-6, in healthy male volunteers during human experimental…

Immunological effects of BCG on vaccination with the yellow fever vaccine.

1) To determine whether vaccination with yellow fever results in a higher cytokine response upon restimulation in vitro with non-related infectious pathogens, compared to the response before the vaccination.2) To determine whether BCG vaccination…

Randomized double blind placebo controlled PK/PD study on the effects of a single intravenous dose of NOX-H94 on serum iron during experimental human endotoxemia

Primary Objective•To assess the pharmacodynamic response after single dose administration of NOX H94 in healthy subjects during experimental endotoxemia.Secondary Objective• To determine the pharmacodynamic effects of NOX H94 after single dose…

The effects of interferon-gamma on sepsis-induced immunoparalysis, a randomised double-blind placebo-controlled pilot (Phase IIIb) study

The primary aim of this pilot-study is to assess safety and the effects on immune function in patients with septic shock of adjunctive therapy with IFN-gamma, in a placebo-controlled manner. The data obtained will allow us to do a powercalculation…

The effects of iron loading and iron chelation during human endotoxemia.

The primary objective of the study is to determine concentration of circulation cytokines na administration of LPS in the presence of iron sucrose (Venofer®), Deferasirox (Exjade®) of placebo.

A Phase I study to evaluate single and multiple (seven) oral doses of SRT2104 on the endotoxin induced inflammatory response in healthy male subjects

Primary objective: To determine if (a) single or (b) 7 daily doses of SRT2104 attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS)Secondary objectives: (1) To determine PK of SRT2104 in…

In vivo effects of C1-esterase inhibitor on innate immune response during endotoxemia in human.

The primary objective is to investigate the effects of intravenous administration of C1INH in human volunteers on cytokine release (TNFa) during endotoxemia. The secondary objective is to determine the effect of administration of C1 INH on…

The effect of enriched enteral nutrition on inflammation and sub-clinical organ dysfunction during human endotoxemia

The primairy goal of the current study is to investigate the effect of enriched nutrition on systemic levels of TNF-alpha.The secundairy goal is to investigate the effect of enriched nutrition on other markers of inflammation, splanchnic perfusion…

The adenosine receptor; a new pharmacological tool in the treatment of sepsis.

Does antagonism of the adenosine receptor by caffeine lead to an increased LPS-induced inflammatory reaction and an increase in (subclinical) tissuedamage?Does the C34T-polymorphism of the enzyme AMP-deaminase lead to a decreased inflammatory…

ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients with Severe Sepsis

The primary objective of this study is to demonstrate that eritoran tetrasodium treatment of patients with severe sepsis results in a reduction in 28-day all-cause mortality.The secondary objectives are to confirm eritoran*s safety profile, and to…

The effect of the α7nACh receptor agonist GTS-21 on inflammation and end-organ dysfunction during human endotoxemia

to study the effect of pre-treatment with the specific a7nAChR agonist GTS-21 on cytokine production and the effects on the subsequent subclinical organ dysfunction in the human endotoxemia model. to measure the effect of LPS administration in the…

Increasing condom use in STI clinic clients: Promoting the formation of Implementation Intentions to overcome the discrepancy between motivation and action.

To assess whether a self-administered intervention to promote the formation of Implementation Intentions successfully promotes the use of condoms in both lower and higher risk clients of an STI clinic and reduces the well-known discrepancy between…

Antibiotic treatment following surgical drainage of perianal abscess: a double-blind, placebo-controlled,
randomized trial.

This study has been transitioned to CTIS with ID 2024-517233-40-00 check the CTIS register for the current data. The objective of this trial is to establish if adding antibiotic treatment to surgical drainage of perianalabscess results in less…

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Assess the Safety and Efficacy of ART-123 in Subjects with Severe Sepsis and Coagulopathy.

The primary objectives of this study are:• To determine whether ART-123, when administered to subjects with infection complicated by at least one organ dysfunction and coagulopathy, can reduce mortality.• To determine the safety of ART-123 in this…