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Effects of BCG vaccination on immunological characteristics of hematopoetic stem cells: an explorative study

To examine the effect of BCG vaccination on the composition and function of the bone marrow.

A Single blind, Placebo controlled, Phase I Dose-ranging Study to Evaluate the Activity of SRT2379 on Endotoxin induced Inflammatory Response in Healthy Male Subjects

Primary objective: To determine if a single administration of SRT2379, at multiple dose levels, attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS)Secondary objectives: (1) To determine…

A Phase I study to evaluate a single oral dose of SRT2379 on the endotoxin induced inflammatory response in healthy male subjects

Primary objective: To determine if a single dose of SRT2379 attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS) Secondary objectives: (1) To determine PK of SRT2379 in normal healthy male…

Randomized double blind placebo controlled PK/PD study on the effects of a single intravenous dose of NOX-H94 on serum iron during experimental human endotoxemia

Primary Objective•To assess the pharmacodynamic response after single dose administration of NOX H94 in healthy subjects during experimental endotoxemia.Secondary Objective• To determine the pharmacodynamic effects of NOX H94 after single dose…

Mesenchymal stromal cell (MSC) transplantation in septic shock.

Evaluation of therapeutic safety and clinical efficacy of MSC transplantation in septic shock.

Effects of oxygen status on Hypoxia Inducible Factor 1-α. A pilot proof of principle study.

The primary objective of the study is to determine the effects of hyperoxia and hypoxia in healthy volunteers on kinetics of HIF1α mRNA in circulating leukocytes. Secondary objectives are to determine the effects of hyperoxia and hypoxia on HIF1α…

A Phase I study to evaluate single and multiple (seven) oral doses of SRT2104 on the endotoxin induced inflammatory response in healthy male subjects

Primary objective: To determine if (a) single or (b) 7 daily doses of SRT2104 attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS)Secondary objectives: (1) To determine PK of SRT2104 in…

The effect of long-term olive-oil based parenteral lipid use on immune functions: a patient-control study

To evaluate immune function and (the susceptibility for) oxidative damage under the influence of long-term olive-oil based TPN use in patients without an active underlying disease and compare this with findings in healthy controls

Absorption of tobramycin from the gut in critically ill patients treated with selective decontamination of the digestive tract (SDD)

To determine whether tobramycin, administered in the gut, permeates from the gut into the blood and is subsequently excreted into the urine.

FAME study: Fecal Administration for eradication of Multiresistant ESBL producing bacteria in carriers

The objective of the study is to see whether donor feces infusions can help to eradicate ESBL in patients who carry ESBL.

the influence of remote ischemic preconditioning on inflammation during human endotoxemia, a pilot proof-of-principle study

To determine the effect of RIPC of the upper limb on the inflammatory response during human endotoxemia (infusion of LPS), as well as the additional effect of 7-day RIPC compared with single-dose RIPC.

Resuscitation Strategies in Septic Shock (ReSSeS). A randomized controlled trial of two different fluid loading strategies in ICU patients with early septic shock.

Our hypothesis in patients admitted to the ICU because of septic shock is that fluid loading guided by transpulmonary thermodilution derived stroke volume variation (SVV) and extravascular lung water (EVLW) results in more ventilator free days (VFDs…

The influence of breathing techniques and exposure to cold on inflammation during human endotoxemia, an explorative study

The primary objective of the present study is to determine the effects of the `strength ventilation` breathing technique and exposure to cold, both separately and in combination, on the inflammatory response during human endotoxemia. To this end, we…

Resuscitation for repair of endothelial permeability in endotoxemia

The main objective of the proposed study is to investigate the effect of plasma products and albumin on markers of endothelial function in a human endotoxemia model.

A study focused at identifying disrupted biological factors and
patient-tailored interventions for adolescents with Q-Fever
Fatigue Syndrome

The first objective is to explore the biological profile (e.g. the immunological profile, hypothalamic- pituitary-adrenal (HPA) axis, mitochondrial dysfunctioning, the gut microbiome) of adolescents with QFS and related fatigue disorders (CFS/ME,…

COrticosteroids for COVID-19 induced loss of Smell - COCOS trial
(AMENDMENT)

To determine the efficacy of a short high-dose treatment of oral prednisolone for persistent loss of smell after COVID-19 infection in the long term (>12 weeks). ADD: determining the clinical course/natural recovery of loss of smell and taste…

Antibiotic treatment following surgical drainage of perianal abscess: a double-blind, placebo-controlled,
randomized trial.

This study has been transitioned to CTIS with ID 2024-517233-40-00 check the CTIS register for the current data. The objective of this trial is to establish if adding antibiotic treatment to surgical drainage of perianalabscess results in less…

Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: a pragmatic randomised controlled trial

To investigate whether analgesic ear drops added to usual care (oral analgesics with/without antibiotics) provide superior ear pain relief over usual care in children presenting to primary care with ear pain and diagnosed with AOM .

ReCOVer: A Randomised Controlled Trial testing the efficacy of Cognitive Behavioural Therapy for preventing chronic postinfectious fatigue among patients diagnosed with COVID-19.

To investigate whether timely delivery of CBT, i.e. 3 to 6 months after COVID-19 diagnosis or hospital discharge, will lead to a significant relevant reduction in fatigue severity (primary outcome), will lead to a clinically relevant reduction in…

Explorative study to the effect of BCG booster methods on the induction of trained innate immunity

The objective of the study is to determine the effect of BCG revaccination and high dose BCG vaccination on the induction and course of innate immune memory.