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Fluids in mechanically ventilated children with acute infectious lung disease: how dry should they be?

This research project aims to determine the feasibility of setting up a randomized controlled trial to study the effects of different fluid management protocols on the outcome of mechanically ventilated pediatric patients with acute infectious lung…

Effect of C1-esterase inhibitor on systemic inflammation in trauma patients with a femur or pelvic fracture.

A previous study of from our laboratory showed that administration of the drug C1-INH (100E/kg) significantly reduced the concentration of circulating pro-inflammatory cytokines, such as IL-6, in healthy male volunteers during human experimental…

Complement activation defects in pediatric oncology patients: hidden factors contributing to the increased risk of infection.

1: Elucidation of the factors that cause the complement deficiency in pediatric oncology patients. First, we will characterize the inhibitor of MASP-2 activity in patients during chemotherapy. 2: Identification of the complement component(s) causing…

A prospective, randomized, intra-patient, comparative, open, multi-centre study to evaluate the efficacy of a Single-Use Negative Pressure Wound Therapy (NPWT) System (PICO) on the prevention of postsurgical incision healing complications in patients undergoing reduction mammoplasty

Primary Objective:To assess the difference in healing complications up to and 21 days post-operatively between postsurgical incisions treated with PICO compared with standard of care Incision healing complications will include;* Skin necrosis*…

Colonisation of highly resistant bacteria in newly hospitalized patients at the OLVG.

The percentage of HRMO Enterobacteriaceae of hospitalized patients at time of admission.

Safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens in patients with rheumatoid arthritis treated with anti TNF-* antibodies (adalimumab) or anti B cell therapy (Rituximab).

To assess the effect of adalimumab and rituximab on the safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens.

In vivo effects of C1-esterase inhibitor on innate immune response during endotoxemia in human.

The primary objective is to investigate the effects of intravenous administration of C1INH in human volunteers on cytokine release (TNFa) during endotoxemia. The secondary objective is to determine the effect of administration of C1 INH on…

The effect of enriched enteral nutrition on inflammation and sub-clinical organ dysfunction during human endotoxemia

The primairy goal of the current study is to investigate the effect of enriched nutrition on systemic levels of TNF-alpha.The secundairy goal is to investigate the effect of enriched nutrition on other markers of inflammation, splanchnic perfusion…

The adenosine receptor; a new pharmacological tool in the treatment of sepsis.

Does antagonism of the adenosine receptor by caffeine lead to an increased LPS-induced inflammatory reaction and an increase in (subclinical) tissuedamage?Does the C34T-polymorphism of the enzyme AMP-deaminase lead to a decreased inflammatory…

The effect of the α7nACh receptor agonist GTS-21 on inflammation and end-organ dysfunction during human endotoxemia

to study the effect of pre-treatment with the specific a7nAChR agonist GTS-21 on cytokine production and the effects on the subsequent subclinical organ dysfunction in the human endotoxemia model. to measure the effect of LPS administration in the…

In vivo effects of the selective a7nAChR agonist GTS-21 on inflammation

Aim of this study is to investigate the effects of oral administration of GTS-21 in healthy volunteers on cytokine release in ex-vivo TLR agonists stimulated whole blood . Pharmacokinetic and pharmacodynamic data will be collected with respect to…

Increasing condom use in STI clinic clients: Promoting the formation of Implementation Intentions to overcome the discrepancy between motivation and action.

To assess whether a self-administered intervention to promote the formation of Implementation Intentions successfully promotes the use of condoms in both lower and higher risk clients of an STI clinic and reduces the well-known discrepancy between…

Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mortality.

The aim of this study is to evaluate if IV albumin administration improves short-term survival in patients with advanced cirrhosis (serum creatinine * 1.2 mg/dl, serum sodium * 130 mEq/l and/or serum bilirubin *4 mg/dl), signs of systemic…

ClOsed Negative-pressure wound Therapy After ColorecTal Surgery

The aim of our study is to investigate whether NPWT in closed incisional wounds decreases the rate of SSI, in patients undergoing laparoscopic or open colorectal surgery with a minimal incisional length of 30mm. Primary Objective: The primary…