Search for a trial

Chemoprophylaxis and Plasmodium falciparum NF54 sporozoite immunization challenged by heterologous infection

Primary objective: To determine whether CPS-immunization with NF54 Plasmodium falciparum parasites provides protection against challenge with the genetically distinct P. falciparum clones, NF135.C10 or NF166.C8.Secondary objectives:• To investigate…

Controlled Human Malaria Infection after bites from mosquitoes infected with NF135.C10 or NF166.C8 Plasmodium falciparum parasites

Primary Objective: To assess the proportion of volunteers who develop parasitemia after Controlled Human Malaria Infection with bites from one, two or five NF166.C8- or NF135.C10-infected mosquitoes.Secondary Objectives: To assess kinetics of…

Immunization with different numbers of Plasmodium falciparum infected mosquito-bites under chloroquine prophylaxis

Primary Objective: To determine if two thirds or one third of the CPS immunization dose still induces complete protection against an experimental malaria challenge. Secondary Objectives: • To study and compare parasitemia and kinetics of parasitemia…

Comparison of three Plasmodium falciparum isolates in an experimental human malaria infection

• Primary objective (parasitological): To investigate the kinetics of parasitemia of different Plasmodium falciparum isolates• Secondary objective (immunological): To investigate parasite development and immunological properties of different…

Immunization with Plasmodium falciparum sporozoites under chloroquine versus mefloquine prophylaxis

Primary Objective: To compare protection against controlled Plasmodium falciparum malaria infection after immunization with sporozoites under chloroquine with immunization under mefloquine prophylaxis. Secondary Objectives: • To study and compare…

Dientamoeba fragilis: clinical symptoms, optimal treatment and molecular detection

1. To determine clinical symptoms of Dientamoeba fragilis infection. 2. To evaluate the efficacy and safety of clioquinol versus metronidazol in the treatment of Dientamoeba fragilis in children.3. To evaluate the duration of positive PCR…

Comparison of three Plasmodium falciparum isolates in a controlled human malaria infection

Primary objective (parasitological): To investigate the parasitaemic kinetics of three different Plasmodium falciparum isolates (NF54, NF135 and NF166) during a controlled human malaria infection.Secondary objective (parasitological, clinical and…

A two-part, randomized, double-blind, placebo-controlled, single-center study to evaluate the safety and causal prophylactic efficacy of KAF156 in a controlled human malaria challenge model

This is a two part proof of efficacy study of KAF156 as a causal prophylactic agent in malaria. Results will be used to guide dose selection for further development of KAF156 in patients.

Phase I and IIa Trial for Assessment of Safety, Immunogenicity (Phase Ia) and Efficacy (Phase IIa) Against Sporozoite Challenge of P. Falciparum Pre-Erythrocytic and Blood Stage (PfPEBS-LSP) Malaria Vaccine Candidate

Using a single formulation of PfPEBS LSP administered at two different doses, one of 5*g and the other one of 30*g, both adjuvanted with aluminium hydroxide, in two immunizations at 28 days interval, to evaluate a) the safety and immunogenicity (…

Randomized, Double-Masked, Placebo-Controlled Multiple-Dose Phase 1 Study to Evaluate the Safety and Tolerability of Different Doses of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects

The primary objective of the study is to establish the ocular safety and tolerability, and systemic safety of 3 different concentrations of preservative-free PHMB in healthy subjects.

Safety and preliminary protective efficacy of genetically attenuated Pf*mei2 (GA2) malaria parasites in healthy Dutch volunteers

Phase 1 • Primary objective: to determine the safety and tolerability, including the attenuation phenotype of a novel late-arresting GAP, named GA2 parasite, administered by sequentially increasing numbers of mosquito bites.• Secondary objective: to…

Coadministration of genetically attenuated Plasmodium falciparum *mei2 (GA2) sporozoites with adjuvants - a proof of principle study

This study has been transitioned to CTIS with ID 2024-516488-99-00 check the CTIS register for the current data. Primary objectives: 1. To assess the effect of experimental immunization with GA2 sporozoites by mosquito bite with and without co-…

Safety and protective efficacy of genetically attenuated Pf*b9*slarp (PfSPZ-GA1) malaria parasites in healthy volunteers

The study is divided in Stage A and BGA1 stage A1. To determine the safety and tolerability of direct venous inoculation of PfSPZ-GA1 in healthy volunteers.GA1 stage B Primary objective:1. To determine the safety, and tolerability of PfSPZ-…