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The influence of a dietary advice consisting of green vegetables, beef and whole dairy products on recurrent upper respiratory tract infections in children, a randomised controlled trial.

A treatment method of a dietary advice of green vegetables, beef and whole dairy products during twelve months including standard supportive care can decrease the number and duration of upper respiratory tract infections compared to standard…

A study to evaluate the relative bioavailability and effect of food on two 450mg MK-3682 Fixed-Dose Combination Formulations (MK-3682 /MK-5172 /MK-8408)

- To evaluate the pharmacokinetic (PK) parameters (AUC0-t, AUC0-*, Cmax, C24, Tmax, and apparent t1/2) of MK-3682 and its circulating metabolites (IDX20664 and IDX23267), MK-5172, and MK-8408 following administration of the fixed-dose combinations…

A study to evaluate the relative bioavailability and effect of food on MK-3682B Fixed-Dose Combination Tablet (MK-3682/MK-8408/MK-5172)

- to evaluate the pharmacokinetic (PK) parameters (AUC0-t, AUC0-*, Cmax, C24, Tmax, and apparent t1/2) of MK-3682 and its circulating metabolites (IDX20664 and IDX23267), MK-5172, and MK-8408 following administration of the fixeddose combination…

The Dolutegravir Antiretroviral Mono-Therapy for HIV Trial

OT population excludes patients lost to follow-up, or that discontinued DTG for reasons of intolerance or toxicity. ITT = all patients that took at least 1 DTG tabletPrimary objective:* To evaluate the efficacy of DTG monotherapy in maintaining…

A Phase 3b, Randomized, Double-Blind Study to Evaluate Switching from a Regimen Consisting of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate (EFV/FTC/TDF) Fixed Dose Combination (FDC) to Emtricitabine/Rilpivirine/Tenofovir Alafenamide (FTC/RPV/TAF) FDC in Virologically-Suppressed, HIV-1 Infected Subjects

Main objective:- To evaluate the non-inferiority of switching to the FTC/RPV/TAF FDC as compared to continuing FTC/RPV/TDF FDC in virologically suppressed HIV-1 infected subjects as determined by maintaining HIV-1 RNA < 50 copies/mL at Week…

A Study to Evaluate the Comparative Bioavailability of Formulation Batches of MK-3682A
Fixed-Dose Combination Tablet (MK-3682/MK-5172/MK-8742, 225 mg/50 mg/25 mg) in
Healthy Adult Subjects

Primary ObjectiveTo evaluate and compare the pharmacokinetic (PK) parameters (AUC0-t, AUC0-inf, Cmax, C24hr, Tmax, and apparent t*) of MK-3682 and its circulating metabolites MK-5172, and MK-8742 following administration of three test premarket…

A single dose study to evaluate the microdose pharmacokinetics of candidate HIV integrase
strand transfer inhibitors in healthy subjects

The purpose of the study is to investigate to what extent L-1, L-2 and L-3 are tolerated when administered as micro-dose.It will also be investigated how quickly and to what extent L-1, L-2 and L-3 are absorbed and eliminated from the body (this is…

Bioequivalence study of crushed Triumeq with or without drip feed compared to the whole tablet.

Primary objectives:To assess the bioequivalence of a single-dose TRI as a whole tablet (reference) compared to a crushed and suspended tablet (intervention I).To assess the bioequivalence of a single-dose TRI as a whole tablet (reference) compared…

Pharmacokinetic analysis of sinecathechins ointment 10% (Veregen) by means of Raman micro-spectroscopy in the skin of healthy volunteers

To gain insight in the pharmacokinetics of sinecathechins ointment 10% (Veregen) applied on healthy skin, using Raman micro-spectroscopy and chromatography of tape strips.

A phase 1, randomized, double-blind, placebo-controlled, escalating single- and multiple-dose study to evaluate the safety, tolerability and pharmacokinetics of EYP001a in healthy male subjects.

In Part 1, a single dose of EYP001a or placebo (same formulation but without the active ingredient EYP001a) will be administered and a total of 6 dose levels of EYP001a will be investigated. The purpose of Part 1 is to investigate how safe EYP001a…

High Flow Nasal Cannula therapy for infants with Bronchiolitis: a randomized controlled trial

To evaluate the effect on severity of dyspnoea of administration of oxygen through High Flow Nasal Cannula compared to oxygen delivery through Low Flow Nasal Prongs in children hospitalized for bronchiolitis with moderate to severe dyspnoea.

A phase 1, open-label study to characterize the absorption, metabolism, and excretion of 14C-JNJ-53718678 after a single oral dose in healthy adult male subjects

The purpose of the study is to investigate how quickly and to what extent JNJ-53718678 is absorbed, distributed, metabolized (broken down) and eliminated from the body. JNJ-53718678 to be administered will be labeled with 14-Carbon (14C) and is thus…

A Phase 1, single-dose, open-label, parallel group study to assess the relative bioavailability of simeprevir, odalasvir and AL-335 when administered in different fixed-dose combination formulations compared to the single agents when administered together, in healthy subjects

Primary Objective•*To evaluate the relative oral bioavailability of SMV, ODV, and AL-335 when administered as different concept fixed-dose combination (FDC) formulations compared to the single agents when administered together, all under fed…

A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SINGLE AND MULTIPLE ASCENDING DOSE STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF RG2459 IN HEALTHY VOLUNTEERS, INCLUDING A SINGLE DOSE PROOF-OF-CONCEPT PART IN PATIENTS INFECTED WITH HEPATITIS C VIRUS, AND A DRUG INTERACTION PART WITH SIMEPREVIR (TMC435) IN HEALTHY VOLUNTEERS

The study will be performed in 4 parts, Parts A, B, C and D. The purpose of the study is to investigate to what extent single doses of RG2459 are tolerated in healthy volunteers and patients with a hepatitis C infection and to what extent multiple…

A Phase 1b, randomized, partially double-blind, placebo-controlled study to assess the
pharmacokinetics, safety, and tolerability of multiple doses of orally administered
JNJ-53718678 in infants hospitalized with RSV infection

Primary Objectives:The primary objectives are to evaluate in infants who are hospitalized with RSV infection:- the pharmacokinetics of JNJ-53718678 after multiple oral doses;- the safety and tolerability of JNJ-53718678 when administered for 7 days.…

The role of renal function in the pharmacokinetics and safety of remdesivir in COVID-19 patients

To determine the influence of renal function and renal replacement therapy on the pharmackinetics and safety of remdesivir in COVID-19 patients.

Management of psoriasis and risk and severity of COVID-19 infection in systemic, biologic and topical treatment for psoriasis during the COVID-19 pandemic: an epidemiological cohort study

Evaluate the point-prevalence, relative risk and severity of COVID-19 infections in psoriasis patients treated with immunosuppressive biologicals or conventional systemic immunosuppressive therapies as compared to topical treatments. Furthermore, we…

RESPIRE - A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Clinical Trial to Evaluate the Safety and Efficacy of ATR-002 in Adult Hospitalized Patients with COVID-19

• To demonstrate the efficacy of ATR-002 versus placebo in addition to standard of care based on the clinical severity status in adult hospitalized patients with COVID-19• To show that ATR-002 in addition to standard of care shortens the time to…

Immune responses Induced by Vaccination Against COVID-19 in Dutch healthy subjects

Monitoring & evaluation of immune responses induced by COVID-19 vaccines in the general population in the Netherlands.

A multiple dosing study to demonstrate the safety, tolerability, pharmacokinetics and efficacy potential of intravenously administered ANXV (a recombinant human Annexin A5) in patients with confirmed moderate to severe COVID-19; The CO-ANNEXIN Study.

Primary Objective:To evaluate the efficacy potential, safety and tolerability of intravenously administered ANXV, in ascending doses, and two different dosing regimens, in patients with confirmed moderate to severe COVID-19.Secondary Objectives:To…